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By We Level Up NJ Treatment Center | Editor Yamilla Francese | Clinically Reviewed By Lauren Barry, LMFT, MCAP, QS, Director of Quality Assurance | Editorial Policy | Research Policy | Last Updated: May 03, 2023

What Is Mescaline?

Mescaline, also called “mescaline drugs,” is a potent hallucinogenic agent extracted from the peyote cactus. It is also recognized by multiple mescaline street names, including “mesc,” “cactus,” “buttons,” and “moon.”

Although natural extract mescaline has been utilized in customary religious rituals for centuries, synthetic mescaline has also emerged as a viable option, frequently advertised as a “legal high” or a replacement for other illegal substances.

Mescaline synthetic is often more potent than organic, increasing the risk of dangerous side effects and overdose. Mescaline extract is obtainable in diverse presentations, encompassing pharmaceutical tablets commercialized as “mescaline pills.”

No matter the terminology or composition, the ramifications of mescaline may be profound and unpredictable, resulting in a prolonged “mescaline trip” that can endure for numerous hours. The ingestion of mescaline may result in various physical and psychological manifestations; besides hallucinations mescaline also produces an aberrant sense of reality and synesthesia.

Although mescaline is derived from a natural source, it can be highly hazardous, especially when consumed in large quantities. It is a common misconception that mescaline is a safe drug. Manifestations of mescaline toxicity may comprise convulsions, tachycardia, hypertension, and fatality.

Recently, there has been an increasing inclination toward employing mescaline as a therapeutic instrument, especially for addressing addiction and other psychological ailments. It is imperative to acknowledge that the therapeutic application of mescaline is presently in its nascent phase, and further investigation is required to comprehend its prospective advantages and hazards comprehensively.

Whether contemplating initial exploration with mescaline or grappling with an addiction to this substance, it is crucial to comprehend the hazards and perils linked to its utilization. If you or someone you know is experiencing adverse mescaline effects, such as addiction or hallucinations, it is imperative to seek medical assistance promptly. It is important to note that the nomenclature of mescaline may differ on the streets; however, the hazards linked with this substance are uniform and can potentially be fatal.

Effects Of Mescaline

Mescaline is a potent hallucinogen that can elicit various effects on the psyche and physiology. The structure of mescaline resembles that of serotonin, a neurotransmitter with significant involvement in regulating mood, appetite, and sleep. The affinity between mescaline and specific receptors in the brain results in the sought-after effects of mescaline experienced by users.

The peyote mescaline cactus is recognized as one of the most prominent origins of mescaline. The mescaline structure is based on the alkaloid compound mescaline derived from the peyote cactus and has been utilized in sacred rituals by various native populations for hundreds of years. Its application has since extended to other regions globally. Currently, mescaline is obtainable in diverse forms, including synthetic variations frequently marketed under the pretense of alternative compounds.

When discussing the effects of mescaline, individuals commonly emphasize the profound visual and auditory hallucinations that may arise due to the substance. In addition to inducing hallucinations, mescaline elicits various other effects such as mood alterations, modified temporal and spatial perception, and somatic sensations like paresthesia.

One of the potential hazards associated with tripping on mescaline is the possibility of unpredictable and heterogeneous effects across individuals. Individuals may exhibit either positive or negative symptoms following the administration of a substance, such as euphoria, spiritual connectedness, anxiety, paranoia, or even psychosis.

It is crucial to acknowledge that the duration of mescaline’s effects can persist for numerous hours, with the climax transpiring approximately 2-3 hours post-consumption. Individuals must be adequately prepared for a prolonged modified consciousness and solely consume mescaline within a secure and regulated setting.

Despite the potential hazards, certain individuals still pursue mescaline and other hallucinogens for their psychoactive properties. It is imperative to delineate mescaline as a substance with potential hazards that may result in severe physiological and psychological health implications.

It is imperative to acknowledge the potential hazards of mescaline usage and seek medical assistance if necessary. Please be advised that the potential effects of mescaline may be severe and uncertain, and procuring mescaline from an unauthenticated source may pose a significant hazard. Ensure your safety and stay informed. Avoid jeopardizing your health and well-being without necessity.

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Mescaline Drug Facts

Mescaline Abuse Overview

Mescaline abuse refers to the non-medical use of the hallucinogenic substance mescaline. Mescaline is found naturally in certain cacti, such as the peyote cactus, but it can also be produced synthetically. The drug can produce intense hallucinations and alter perceptions of reality, leading to potential psychological and physical harm. Mescaline abuse can have serious consequences and should be addressed through proper treatment and support.

Mescaline Addiction Treatment

Treatment for Mescaline addiction often involves a combination of therapy, counseling, and support programs. Treatment aims to address the root causes of addiction, provide coping mechanisms, and help individuals maintain long-term sobriety. Treatment may be provided on an outpatient or inpatient basis, depending on the severity of the addiction. Support groups, such as Narcotics Anonymous, can also be helpful for those in recovery from Mescaline addiction.

Mescaline Abuse Symptoms

Symptoms of Mescaline abuse can vary depending on the individual and the frequency and amount of drug use. Some common symptoms of Mescaline abuse may include:

  • Visual and auditory hallucinations.
  • Altered perceptions of reality and time.
  • Increased heart rate and blood pressure.
  • Dilated pupils.
  • Sweating and chills.
  • Nausea and vomiting.
  • Loss of appetite.
  • Insomnia and sleep disturbances.
  • Paranoia and anxiety.
  • Mood swings and emotional instability.
  • Disorientation and confusion.

It is important to seek professional help if you or someone you know exhibits these symptoms, as they may indicate a problem with Mescaline abuse.

Mescaline Abuse Statistics

Mescaline abuse statistics shed light on the prevalence and impact of this hallucinogenic drug on individuals and communities. The data highlights the risks and dangers of Mescaline abuse, including physical and psychological harm, addiction, and potential long-term consequences. Understanding Mescaline abuse statistics is crucial in addressing and developing effective prevention and treatment strategies.


Approximately 0.2% of individuals aged 12 and older reported using hallucinogens, including Mescaline, in the past month.

Source: National Survey on Drug Use and Health


Mescaline-related emergency department visits increased by 293% from 2007 to 2011.

Source: Drug Enforcement Administration


there were over 4,000 admissions to treatment centers for hallucinogen use disorders, including Mescaline, in 2019.

Source: Substance Abuse and Mental Health Services Administration

  1. Whats Mescaline? Define Mescaline.

    Mescaline is a potent hallucinogen in various cacti species, such as the peyote cactus. Synthetic production is also feasible.

  2. Where Does Mescaline Come From?

    The primary source of mescaline is the peyote cactus, indigenous to Mexico and certain regions of the southwestern United States. It is also present in other cacti species, including the San Pedro.

  3. How Long Does Mescaline Last?

    Mescaline’s effects may persist for multiple hours, with the climax manifesting approximately 2-3 hours post-ingestion. The duration of the effects may vary based on variables such as the administered dosage, personal tolerance, and route of administration.

  4. Is Mescaline Legal?

    The regulatory status of Mescaline is subject to regional variation. The possession and utilization of Mescaline is considered illegal under federal law in certain countries, including the United States. However, certain indigenous communities can utilize peyote during their spiritual rituals.

  5. Mescaline, Where To Buy?

    The procurement of Mescaline (mescaline buy) is prohibited in numerous nations. Certain individuals may endeavor to procure Mescaline through online means. However, this action may pose a potential hazard and is frequently considered illicit. It is imperative to acknowledge that assessing the quality and purity of substances procured online can pose a challenge.

  6. How To Make Mescalin?

    The synthesis of Mescaline can be a multifaceted procedure and is considered illicit in most nations. The procedure entails the extraction of the active compound from the cactus or its synthesis in a controlled laboratory setting. The synthesis of Mescaline is a highly hazardous procedure and should never be undertaken by individuals lacking professional expertise.

What Is Mescaline? Mescaline and LSD are two of the most well-known hallucinogens, and while they share some similarities, they also have distinct differences.
What Is Mescaline? Mescaline and LSD are two of the most well-known hallucinogens, and while they share some similarities, they also have distinct differences.

Mescaline Vs LSD

Mescaline and LSD are forms of prominent hallucinogenic substances with similarities and differences in their effects. Mescaline, or Mescal or Mescalito, is a hallucinogenic compound found in specific cacti species, including the peyote cactus.

Synthetic production of the substance in powder form is also feasible. On the contrary, LSD, also known as lysergic acid diethylamide, is a synthetic substance that bears a chemical resemblance to serotonin, a neurotransmitter found in the brain.

Mescaline and LSD are hallucinogenic substances that can induce profound visual and auditory hallucinations and modify an individual’s perception of reality. Nevertheless, the two compounds exhibit significant dissimilarities in their impact, duration, and legality.

A fundamental dissimilarity between Mescaline and LSD pertains to the length of their respective effects. It is widely acknowledged in the medical community that mescaline has a longer onset and duration compared to LSD, with its effects persisting for a period of 12 hours or more. In contrast, LSD exhibits a briefer onset and duration, with its effects typically subsiding within 6-8 hours.

An additional distinguishing factor between the two compounds pertains to their legal status. Although Mescaline and LSD are prohibited in the United States, Mescaline is categorized as a Schedule I substance according to the Controlled Substances Act. This indicates that it is more likely to be abused and lacks any recognized medical application. However, LSD is categorized as a Schedule I substance, although it has been utilized in certain medical research investigations.

Acquiring Mescaline and LSD can pose a challenge in terms of procurement. Although Mescaline powder may be obtainable through illicit means, it is prohibited by law and poses potential hazards due to contaminants and adverse reactions. LSD may be obtained as blotter paper or liquid; however, it is an illicit substance frequently synthesized in covert laboratories.

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Mescaline Vs Psilocybin & Mescaline Dosage

Even though mescaline and psilocybin, two of the most well-known natural psychedelic substances, have some things in common, they are also quite different. Some cacti, like the peyote cactus, naturally contain the psychedelic compound mescaline. However, “magic mushrooms,” which contain the psychoactive compound psilocybin, are only found in a few species.

The mescaline dose and dose-response relationships are among the most notable distinctions between Mescaline and Psilocybin. Mescaline’s hallucinatory effects are dose-dependent, meaning different people can experience them with different amounts of the drug. Some users may take as much as 1 gram of Mescaline, but the normal dose is between 200 and 500 milligrams. Compared to Mescaline, the active dose of Psilocybin is much lower, typically between 10 and 30 milligrams.

The effects of Mescaline and Psilocybin also manifest at different times and last for different amounts of time. Mescaline’s effects can last up to 12 hours, making it a more time-intensive trip than Psilocybin. Psilocybin, on the other hand, has effects that last anywhere from four to six hours at the most. Mescaline’s physical symptoms, such as nausea and vomiting, are more severe than Psilocybin’s.

In the United States, the Controlled Substances Act classifies mescaline and psilocybin as Schedule I substances due to their significant abuse potential and lack of recognized medicinal value. However, Psilocybin’s therapeutic potential has recently received more attention, particularly as a possible treatment for depression and anxiety.

Mescaline and Psilocybin can cause extreme hallucinations of sight and sound and distort one’s view of the world. Psilocybin is recognized for its mystic and introspective effects, whereas Mescaline causes more drastic shifts in perception and awareness.

In sum, as natural psychedelics, Mescaline and Psilocybin have some things in common but are also distinct regarding dosage, duration of effects, and impacts on perception and awareness. Both drugs are illegal in the United States and pose serious health risks to anyone who uses them. Those battling substance misuse should carefully examine the hazards and benefits of these substances before deciding to use them.

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Mescaline Addiction Treatment

Mescaline is a powerful hallucinogenic drug that can cause intense, long-lasting mental and physical effects. Unfortunately, some people may become addicted to mescaline and require professional treatment to overcome their addiction.

The first step in treating mescaline addiction is typically detoxification. During detox, a person stops using the drug and allows it to leave their system completely. This process can be uncomfortable and dangerous, so seeking medical supervision during detox is important.

After detox, individuals with mescaline addiction may benefit from a variety of treatment options, including:

 Behavioral therapy can be conducted one-on-one or in a group setting, including cognitive-behavioral therapy (CBT), motivational interviewing (MI), and contingency management.
Behavioral therapy can be conducted one-on-one or in a group setting, including cognitive-behavioral therapy (CBT), motivational interviewing (MI), and contingency management.
  • Behavioral Therapy: This therapy is designed to help individuals understand the root causes of their addiction and learn new coping mechanisms to deal with cravings and triggers. Behavioral therapy can be conducted one-on-one or in a group setting, including cognitive-behavioral therapy (CBT), motivational interviewing (MI), and contingency management.
  • Support Groups: Support groups like Narcotics Anonymous (NA) and Alcoholics Anonymous (AA) can be important sources of support and guidance for individuals in recovery. These groups provide a safe, non-judgmental space where people can share their experiences and struggles with others who have gone through similar experiences.
  • Medications: While no specific medications are approved for treating mescaline addiction, certain medications may be used to manage withdrawal symptoms or co-occurring mental health conditions. For example, antidepressants may be prescribed to individuals with depression or anxiety, common co-occurring conditions among those with addiction.

It’s important to note that no one-size-fits-all approach to treating mescaline addiction exists. The most effective treatment plan will depend on the individual’s unique needs and circumstances. That’s why it’s important to seek help from a qualified addiction treatment professional who can help create a personalized recovery plan.

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What is Mescaline? We Level Up Dual Diagnosis Treatment

The definition of dual diagnosis (also referred to as co-occurring disorders) can differ between institutions. However, it is generally described as the specific treatment of someone diagnosed with a substance use disorder and a mental health disorder simultaneously. Treating dual-diagnosis clients is a critical aspect of our inpatient treatment experience because co-occurring disorders are strongly correlated with instances of substance abuse.

Creating a treatment plan that addresses the physical aspects of withdrawal, the psychological connection with drug use, and managing underlying mental health disorders is part of setting clients up for success. A thorough mental health analysis identifies possibilities for treatment. Meeting with mental health counselors and medical care providers means access to behavioral therapy and medication treatment. At our dual diagnosis treatment center, We Level Up can implement the highest quality of care. 

We understand the delicate complexity of the interconnectedness of mental and substance abuse illnesses and how they can perpetuate addiction’s revolving door. We offer specialist treatment to give those with a dual diagnosis the best possible shot at a full and lasting recovery.

Accepting that you may be living with a mental illness can be challenging. However, treating the presenting substance abuse case can be magnitudes easier once properly diagnosed and treated. Only a properly trained medical professional can diagnose these underlying conditions. If you believe you are suffering from a disorder alongside addiction, we urge you to seek a qualified treatment center to begin your journey to recovery. Call We Level Up today.

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