Is It Safe To Mix Cocaine and Alcohol?

Mixing cocaine and alcohol can lead to dangerous, even life-threatening consequences due to the formation of a toxic chemical called cocaethylene.

Mixing Cocaine and Alcohol

Alcohol is often consumed alongside other illicit substances, making some wonder what happens when you mix cocaine and alcohol. Mixing cocaine and alcohol can lead to dangerous, even life-threatening consequences due to the formation of a toxic chemical called cocaethylene. Thus, it is critical to avoid using cocaine mixed with alcohol.

Whether you take cocaine occasionally, regularly, or have used it once or twice, it is crucial to understand the risks of mixing it with alcohol. Both substances affect the mind and body, even when taken alone, and there are even more significant risks when consumed together.

There’s a myth out there about using cocaine and alcohol together. People believe taking both can boost the cocaine high and help avoid withdrawal. This is just not true. Mixing alcohol and cocaine (or “alcohol y cocaina” in Spanish) can have deadly results. Cocaine and alcohol don’t negate the effects of one another. They mask the products, making people unaware of how inebriated they are.

As cocaine is a stimulant and alcohol is a depressant, the collective pressure they put on your body and mind can be dangerous. Some people use coke and alcohol drinks simultaneously to increase the effects of both substances. However, this combination can easily lead to life-threatening consequences such as overdose or alcohol poisoning.

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What Happens When You Mix Alcohol and Cocaine?

Cocaine is snorted and goes to the liver via nasal vessels. On the other hand, alcohol reaches the liver via circulation. Cocaethylene is a cocaine and alcohol metabolite that is created when both are consumed together.  

Cocaethylene has pharmacological properties similar to cocaine but has a plasma half-life of three to five times that of cocaine. Cocaethylene is a cocaine and alcohol compound that has been associated with seizures, liver damage, and compromised immune system functioning. It also carries an 18- to 25-fold increase over cocaine alone in risk for immediate death.

Cocaine-alcohol produced greater euphoria and increased perception of well-being relative to cocaine. Heart rate significantly increased following cocaine-alcohol administration comparable to either drug alone. Cocaine concentrations were greater following cocaine-alcohol administration. Cocaethylene had a longer half-life with increasing concentrations relative to cocaine at later time points.

Enhanced psychological effects during cocaine-alcohol abuse may encourage the ingestion of more significant amounts of these substances over time, placing users at heightened risk for greater toxicity than with either drug alone.

Toxic levels of cocaethylene build-up in the liver have been linked to sudden death as well as the following negative physical consequences:

  • Myocardial infarction (or painful heart attack)
  • Cerebral infarction (damage to brain tissue, leading to stroke or aneurysm)
  • Intracranial hemorrhage (bleeding in the brain)
  • Cardiomyopathy (heart disease)
  • Cardiac arrhythmia (irregular heartbeat)
Cocaine and Alcohol
Mixing cocaine with alcohol has been associated with a greater risk of suicidal tendencies. Prolonged use can also take a toll on your long-term physical health, which can be life-threatening.

Effects of Cocaine and Alcohol Mixed

Can you mix cocaine and alcohol? Mixing coke with alcohol increases the risk of having a heart attack or experiencing respiratory failure, a life-threatening condition characterized by an inability to breathe. Alcohol causes both stimulant and depressant effects. Mixing cocaine alcohol causes more harm to the heart and other vital organs than using either drug on its own. 

Using multiple drugs at once can also increase the risk of addiction. Drugs manipulate the pleasure and reward system in the brain. When a person uses cocain drinks alcohol simultaneously, multiple plans in the brain are disrupted, and they may become addicted to multiple drugs.

Both coca alcohol have negative long-term effects on the body. With chronic cocaine use, the brain adapts to this new synthetic happiness by stopping the production of naturally occurring dopamine. Along with this, the neural circuits involved in stress become increasingly sensitive, leading to increased negative moods and irritability when not taking the drugs.

Long-time users of alcohol also face a whole host of psychological and physical issues. Heavy drinking can significantly contribute to alcohol liver damage, including alcoholic hepatitis and cirrhosis. It can contribute to cardiological issues such as cardiomyopathy, high blood pressure, and an increased chance of stroke or heart attack. Heavy long-term alcohol use has also been associated with many cancers, including mouth, throat, larynx, colorectal, liver, and esophageal cancer.

Side Effects of Cocaine and Alcohol Together

Taking alcohol and coke together can amplify the personal side effects of each substance. Additionally, there are many long-term and short-term side effects associated with alcohol and cocain mix. alcohol and cocaine interactions include:

  • Cardiotoxicity (heart toxicity)
  • Breathing problems
  • Increased heart rate
  • Cognitive impairment
  • Increased blood pressure
  • Loss of coordination and motor function
  • Violent thoughts and threats
  • Heart palpitations
  • Cerebral infarction (death of blood vessels and blood tissue)
  • Stroke
  • Death

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Cocaine and Alcohol Abuse

Alcohol abuse, also known as alcoholism, is a disease that affects people from all walks of life. In 2018, the World Health Organization (WHO) [3] reported that alcohol contributed to more than 200 diseases and injury-related health conditions, ranging from liver diseases, road injuries, and violence to cancers, cardiovascular diseases, and suicides. What is the effect of bad coke on the body? Taking cocaine on itself is already bad; mixing it with alcohol can worsen it. It is recommended to avoid alcohol when taking any other substances.

Alcohol is a psychoactive substance with dependence-producing properties. One of the most important facts to remember about alcoholism is its progression. It begins in an early stage that looks nothing like a life-threatening disease, proceeds into a middle stage where problems start to appear and intensify, and gradually advances into the late, degenerative stages of evident physiological dependence and physical and psychological deterioration.

Because alcohol is encouraged by our culture, we get the idea that it isn’t dangerous. However, alcohol is the most potent and toxic of the legal psychoactive drugs. Alcoholism is a devastating, potentially fatal disease. The primary symptom of having it is telling everyone–including yourself–that you are not an alcoholic.

Cocaine and Alcohol
Cocaine and alcohol makes a toxic chemical called cocaethylene. Using both drugs simultaneously strains the heart, injures the liver, and damages the brain.

Understanding Alcohol and Cocaine Abuse

Before understanding how cocaine interacts with alcohol, we first need to learn how cocaine impacts the body. Cocaine is an illegal stimulant that is also overly abused. Cocaine can be used as crack cocaine or in a powdered form. To increase profits, many cocaine dealers mix the substance with “cornstarch, talcum powder, or flour.” They may “also mix it with other drugs such as the stimulant amphetamine, or synthetic opioids including fentanyl.”

These different substances make a dangerous compound, as “adding synthetic opioids to cocaine is especially risky when people using cocaine don’t realize it contains this dangerous additive. Increasing overdose deaths among cocaine users might be related to this tampered cocaine.”

Whether the user knows if the cocaine has an additive or not, they most likely will proceed with its use. In most cases, people snort the powdered form through their noses or rub it into their gums. The powder can also be dissolved and injected into the bloodstream. Once cocaine is processed, it is called “freebase cocaine.”

In the heating process, the crystal rock makes a crackling sound. The crystal is heated to create vapors that can be inhaled into the lungs. Cocaine can also be used with other substances. A stronger combination than cocaine and beer is cocaine and heroin, known as a speedball.

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Alcohol and Cocaines

People use alcohol with coke to self-medicate and dull emotional anxiety or depressive mood. Alcohol and drug use is a common coping mechanisms. When the coping mechanism becomes polydrug use, multiple diagnoses are at play. In most cases, people begin self-medicating to avoid understanding their symptoms and lack an appropriate diagnosis.

Individuals with schizophrenia and bipolar disorder are especially at risk of substance abuse and polydrug patterns. Research has shown that a particular demographic is more likely to develop an alcohol use disorder; people with bipolar disorder. This is because of the attempt to modulate mania linked with the condition.

Individuals suffering from bipolar disorder tend to use alcohol coke and are also susceptible to developing an addiction to cocaine to modulate the effects of the depressive episodes. While these individuals with either undiagnosed or diagnosed bipolar disorder use these drugs to alleviate their symptoms, the combinations of drug use make mood disorders like anxiety, depression, and bipolar worse for various reasons.

Polydrug use is, unfortunately, more common than we like to think, and one drug does enough harm to the body alone when abused. Both medicines can cause damage to the user’s body and social and emotional well-being while also increasing their risk of long-term, chronic health issues or overdose. The health dangers of one drug are enhanced by polydrug use and dual diagnoses.

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Cocaine and Alcoholism Treatment

Treatment for a cocaine vs alcohol addiction typically involves medically-assisted detox and therapy in an inpatient rehabilitation program. These programs greatly increase your chances of a successful recovery, even though psychological dependence on cocain and alcohol is a severe condition that is difficult to overcome. If you are considering coke alcohol mix addiction treatment, seeking a substance abuse evaluation from an addiction professional helps determine the right type of support.

Finding treatment for cocaine and alcohol (or “cocaina y alcohol” in Spanish) addiction is the first step toward recovery. It is also the most important step. Once you admit that you’re struggling with cocaine and alcohol addiction, the only way forward is. 

The brain does not return to normal when drug and alcohol use stops. It could take several supports, therapy, counseling, and treatment methods to help you effectively overcome the disease. Not everyone needs cocaine addiction treatment, but such help benefits those who have suffered adverse reactions to their sustained drug use, including cocaine overdose

Treatment for cocaine addiction may include:

There are thousands of treatment centers in the country, but not all are right for everyone. Those looking for help need to find a center that specifically offers cocaine and alchol addiction treatment. This center must also be able to treat other drugs and co-occurring mental conditions if you or a loved one is struggling with cocaine and alcohol addiction. We Level Up NJ addiction specialists are standing by to help.

Cocaine and Alcohol
Many who seek to stop using cocaine and alcohol choose to enter medical detox, an intervention designed to help you safely and comfortably eliminate both substances from your body.

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Can you drink cocaine? Is drinking cocaine safe?

Both the traditional act of cocaine drinking and eating it are uncommon. Although most people do not ingest cocaine, it is not unusual for someone to wipe the white powder form of the drug along their gums. Therefore, it is not recommended to drink cocaine.

Does coke sober you up?

Mixing cocaine and alcohol does not make a person sober up faster. It only makes you think you are sober.

What is Cocaethylene?

Cocaethylene forms in the liver when cocaine and ethanol coexist in the blood.

Can you put cocaine in a drink?

It is extremely uncommon to ingest cocaine, let alone put it in a drink. When taking cocaine, avoiding other substances, such as alcohol, is best to prevent worsening side effects.

What happens if you drink cocaine?

If you eat or drink cocaine, dangerous and potentially life-threatening side effects may occur.

Is alcohol worse than cocaine? Or is cocaine worse than alcohol?

Depending on the dose, there are cases where alcohol vs cocaine is worse. But in most cases, cocaine is still worse than alcohol.

Does cocaine give you a hangover?

Yes, excessive amounts of cocaine lead to overdose and potential hangover. You risk worsening side effects when taking cocaine excessively.


[1] NCBI –

[2] NCBI –

[3] WHO –