The Dangers of Taking Trazodone and Alcohol Together. Trazodone Interactions With Alcohol. Can You Take Trazodone With Alcohol?

Trazodone is given to people with depression, anxiety, or insomniacs. It can work as recommended, but taking Trazodone and alcohol can harm you.

Mixing Trazodone and Alcohol

Trazodone is a commonly prescribed medication for depression, anxiety, and insomnia. While it can be effective when prescribed, combining Trazodone with alcohol can pose severe risks to your health. We will explore the dangers of taking Trazodone and alcohol, the potential side effects, and why avoiding this dangerous combination is essential.

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What is Trazodone?

Trazodone is a medication primarily prescribed for the treatment of two main conditions:

  • Depression: Trazodone belongs to a class of drugs known as serotonin modulators. It works by increasing serotonin levels, a neurotransmitter, in the brain. This, in turn, can help improve mood and alleviate symptoms of depression.
  • Insomnia: Trazodone is sometimes prescribed off-label for its sedative effects, particularly to treat insomnia. While not initially developed as a sleep aid, its ability to induce drowsiness can help individuals with sleep difficulties fall and stay asleep.

Trazodone is available in oral tablet form and is generally taken before bedtime. Its sedative properties make it suitable for individuals struggling with depression and sleep problems.

Trazodone can help treat these conditions, but it may have side effects or combine with other drugs, so it should only be taken with a doctor’s advice and supervision. Depending on the condition being treated, the treatment dose and length will differ, and changes may be made to get the best therapeutic results while minimizing side effects.

Can You Take Trazodone With Alcohol?

Trazodone is a medication primarily prescribed for the treatment of depression and insomnia. It belongs to a class of drugs known as serotonin modulators, which increase serotonin levels in the brain. While Trazodone can effectively manage these conditions when used appropriately, combining it with alcohol is generally discouraged. Here’s why:

The Trazodone Alcohol Combination

  • Increased Sedation: Both Trazodone and alcohol have sedative effects. Combining them can significantly amplify drowsiness, making driving or operating heavy machinery dangerous.
  • Impaired Cognitive Function: Alcohol impairs cognitive function, and Trazodone can enhance this effect. Individuals who mix the two may experience difficulties with concentration, memory, and decision-making.
  • Risk of Overdose: Consuming alcohol with Trazodone increases the risk of overdose. Both substances can depress the central nervous system, potentially leading to life-threatening complications like respiratory depression and loss of consciousness.
  • Mood and Behavior Changes: Combining Trazodone and alcohol can result in unpredictable mood swings and behavior changes. This may include worsening symptoms of depression or other mental health conditions.
  • Gastrointestinal Problems: Mixing Trazodone and alcohol can lead to stomach issues, including nausea, vomiting, and gastrointestinal bleeding.
  • Worsened Mental Health Symptoms: Alcohol is a depressant, and its interaction with Trazodone can worsen symptoms of anxiety or depression. It can also diminish the therapeutic effects of the medication.
  • Reduced Effectiveness of Trazodone: Alcohol can decrease the effectiveness of Trazodone in managing mental health conditions, potentially leading to inadequate symptom control.

How Risky is the Trazodone & Alcohol Combination?

The combination of Trazodone and alcohol is risky, leading to increased drowsiness, impaired cognitive function, reduced medication effectiveness, a higher risk of overdose, potential liver strain, and unknown interactions that could compromise your health and safety. It is highly advised to avoid alcohol when taking Trazodone and to consult your healthcare provider for guidance on medication usage.

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Alcohol and Trazodone Fact Sheet

Trazodone and Alcohol Overview

Alcohol, as a depressant, has a pronounced impact on the central nervous system, causing relaxation and sedation. Trazodone, on the other hand, is a commonly prescribed medication primarily used to treat conditions like depression and insomnia. Understanding the potential risks of combining Trazadone and alcohol is crucial for maintaining your health and safety.

Potential Dangers of Trazodone Mixed With Alcohol

  • Increased Drowsiness: One of the most significant risks when combining alcohol and Trazodone is the intensification of drowsiness. Both substances independently induce drowsiness, but together, their effects are synergistic. This can result in extreme sedation, impairing cognitive function and motor skills. Engaging in activities like driving or operating heavy machinery under these conditions can be highly dangerous.
  • Reduced Medication Effectiveness: Alcohol consumption can diminish the effectiveness of Trazodone, potentially interfering with the medication’s intended therapeutic benefits. This means that individuals taking Trazodone for conditions such as depression or insomnia may not experience the relief they need.
  • Risk of Overdose: Combining alcohol and Trazodone increases the risk of overdose on the medication. Trazodone overdose can result in various health complications, including dangerously low blood pressure, irregular heart rhythms, and coma. In such cases, immediate medical attention is essential.
  • Liver Strain: Both alcohol and Trazodone are metabolized in the liver. Drinking alcohol can strain this vital organ, and combining it with Trazodone can potentially exacerbate liver complications. Individuals with pre-existing liver conditions are particularly vulnerable to these effects.
  • Unknown Interactions: The full extent of interactions between Trazodone and alcohol is not comprehensively documented. This means unpredictable and potentially harmful interactions can occur, posing severe health risks and compromising well-being.


  • Avoid Alcohol: Given the potential risks and dangers, it is strongly recommended to abstain from alcohol when taking Trazodone. This precaution helps ensure your safety and the effectiveness of your prescribed medication.
  • Consult a Healthcare Provider: If you have concerns or questions about Trazodone and its interactions with alcohol, it is advisable to consult your healthcare provider. They can provide personalized guidance and address your questions or situations.

Additional Considerations

  • Tolerance and Dependence: Chronic alcohol consumption can lead to tolerance and physical dependence. This can complicate Trazodone treatment, as higher doses may be needed to achieve the same therapeutic effects. It’s essential to recognize the potential consequences of developing alcohol tolerance and dependence alongside Trazodone use.
  • Mental Health Impact: Combining Trazadone with alcohol can negatively affect mental health. Both substances can contribute to symptoms of depression, anxiety, and mood swings, making it challenging to manage mental health conditions effectively.
  • Interaction with Other Medications: If you are taking other medications along with Trazodone, the risks of interactions can increase. The presence of alcohol in the mix can further complicate these interactions, potentially affecting the safety and efficacy of your medication regimen.
  • Withdrawal Symptoms: Abruptly discontinuing Trazodone or alcohol can lead to withdrawal symptoms. Combining and discontinuing both substances may result in more severe withdrawal effects. It’s crucial to seek medical advice when considering changes in medication or alcohol use.

Alcohol and Trazodone Statistics

High-intensity drinking is a new trend discovered by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Alcohol consumption “at levels that are two or more times the gender-specific binge drinking thresholds” is included in the definition of high-intensity drinking (HID).

There isn’t much peer-reviewed research because it’s still a new trend. According to the information that is currently available, HID is widespread among binge drinkers and is frequently related to essential occasions, particularly 21st birthdays and athletic events.


140,557 Americans die from the effects of alcohol in an average year.

Source: NIAAA


1-in-10 Americans over the age of 12 have an Alcohol Use Disorder.

Source: NIAAA


Over half of Americans increased their alcohol consumption during COVID-19 lockdowns.

Source: NIAAA

Trazodone and Alcohol Death Rates

Some users of the antidepressant and sedative medicine trazodone have reported drowsiness, dizziness, and impairment of cognitive and motor functions. When combined with alcohol, these side effects become even more pronounced, increasing the likelihood of accidents and injuries and causing extreme sleepiness and confusion.

Furthermore, the CNS depressant Trazodone, combined with heavy alcohol intake, can lead to respiratory depression, hypotension, and loss of consciousness. Coma or death may result in extreme circumstances.

Although significant injury, even death, is possible, it is crucial to stress that the chance of these consequences varies significantly from person to person. It’s best not to mix the two; if you’re having trouble with alcohol or mental health, you should get help. It is essential to talk to medical doctors, addiction specialists, or mental health professionals to get the help you need.

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Can You Take Trazodone for Alcohol Withdrawal?

Trazodone is not a medication typically prescribed to treat alcohol withdrawal symptoms. The primary medical treatments for alcohol withdrawal usually involve benzodiazepines, such as diazepam or lorazepam. These medications are prescribed to manage and mitigate the potentially severe and dangerous withdrawal symptoms associated with alcohol cessation, including seizures and delirium tremens.

Trazodone is an antidepressant primarily used to treat conditions like depression and insomnia. While it may help with sleep disturbances or underlying mental health issues that could contribute to alcohol misuse, it is not considered a first-line treatment for alcohol withdrawal.

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Can you Overdose on Trazodone With Alcohol?

Yes, it is possible to overdose on Trazodone, especially when combined with alcohol. Trazodone is an antidepressant medication, and an overdose can lead to a range of symptoms, including:

  • Excessive Sedation: Trazodone is known for its sedative effects. Taking too much, especially with alcohol, can lead to extreme drowsiness and a significant decrease in alertness.
  • Dizziness and Impaired Coordination: Overdosing on Trazodone can result in severe dizziness and loss of balance. This is exacerbated when combined with the impairing effects of alcohol.
  • Low Blood Pressure: Trazodone overdose may lead to low blood pressure (hypotension), which can cause fainting, dizziness, and in severe cases, can be life-threatening.
  • Cardiac Arrhythmias: In some cases, Trazodone overdose can affect the heart’s electrical conduction, leading to abnormal heart rhythms (arrhythmias).
  • Respiratory Depression: Trazodone overdose can suppress the central nervous system, leading to slow or shallow breathing, which can be dangerous.

The presence of alcohol in the body exacerbates these effects. Alcohol is also a depressant and can amplify Trazodone’s sedative and central nervous system-depressing effects. This increases the risk of overdose and its associated complications.

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  1. Can you drink alcohol with trazodone? Can I take trazodone after drinking alcohol?

    It is generally not advisable to drink alcohol while taking Trazodone. Alcohol can interact with Trazodone, increasing its sedative effects and potentially leading to adverse reactions, including dizziness, drowsiness, and impaired coordination. This combination can be unsafe and is best avoided.

  2. Does trazodone help with alcohol withdrawal?

    Trazodone is not a primary medication for alcohol withdrawal treatment. It is an antidepressant with sedative properties. Alcohol withdrawal should be managed with appropriate medical care and medications specifically designed for this purpose. Consult a healthcare provider for guidance on alcohol withdrawal treatment.

  3. Can you mix trazodone and alcohol?

    While it is physically possible to mix Trazodone and alcohol, it is not advisable. Combining the two substances can increase the risk of side effects, sedation, and other adverse reactions. It’s best to avoid using them together and consult a healthcare professional for guidance on the safe use of medications and alcohol.

  4. Can you mix Trazodone And Wine?

    Mixing Trazodone and wine can be dangerous and is not recommended. Trazodone is a prescription medication used to treat depression and insomnia, and alcohol can interact with it, potentially increasing its sedative effects and causing adverse reactions. It’s essential to consult with a healthcare professional for specific advice regarding your situation.

  5. Can Taking Trazodone With Alcohol Make You Die?

    Mixing Trazodone with alcohol can be extremely dangerous and, in some cases, life-threatening. Trazodone and alcohol can depress the central nervous system, leading to increased sedation and a higher risk of overdose. Combining them may cause extreme drowsiness, dizziness, impaired coordination, slowed breathing, and a significant risk of respiratory depression, potentially leading to death.

  6. Can Trazodone Help With Alcohol Withdrawal?

    Trazodone is not typically used as a first-line treatment for alcohol withdrawal. The primary approach to managing alcohol withdrawal syndrome (AWS) involves supportive care, addressing dehydration and electrolyte imbalances, and preventing complications like seizures and delirium tremens. Medications such as benzodiazepines (e.g., diazepam or lorazepam) are often prescribed to manage withdrawal symptoms and prevent seizures.

  7. Are Trazodone And Alcohol Withdrawal Related?

    During alcohol withdrawal, individuals may experience sleep disturbances, anxiety, and depression, among other symptoms. Trazodone is an antidepressant with sedative properties often prescribed to treat insomnia and depressive symptoms. Sometimes, a healthcare professional may prescribe trazodone to help manage sleep problems and mood disturbances associated with alcohol withdrawal.

Suffering from Trazodone Interactions With Alcohol? Watch the Alcoholism Treatment Video

Alcoholism, also referred to as alcohol addiction or alcohol dependency, is a form of disorder related to the consumption of alcohol. This disorder is identified by regular and excessive alcohol intake that eventually leads to dependency, where drinking becomes an integral part of an individual’s life. Different methods are utilized in alcoholism therapy to aid individuals in quitting binge drinking and addressing the disorder.

Search The Dangers of Taking Trazodone and Alcohol Together/ Detox & Mental Health Topics & Resources
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  4. Food and Drug Administration. (2010). OLEPTRO.
  5. Victoria State Government. (2012). Alcohol and the Brain.
  6. Bowling Green State University. Effects of Alcohol.
  7. Substance Abuse and Mental Health Services Administration. (2018). Key Substance Use and Mental Health Indicators in the United States: Results from the 2017 National Survey on Drug Use and Health.
  8. Evans, E. and Sullivan, M. (2014). Abuse and misuse of antidepressantsSubstance Abuse and Rehabilitation, 5, 107-120.
  9. Tinsley, J., Olsen, M., Laroche, R., and Palmen, M. (1994). Fluoxetine AbuseMayo Clinic Proceedings, 69(2), 166-168.
  10. University of Michigan Medicine. Trazodone. Learn More: trazodone mixed with alcohol
  11. Medline Plus. Trazodone. trazodone and alcohol interactions
  12. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing. Learn more: trazodone and alcohol interactions