Dose of MDMA, Effects of MDMA Overdose

MDMA is a stimulant drug with euphoric and hallucinogenic properties. Find out information about the fatal dose of MDMA, its effects, and tips to stay safe. Read more about the different treatment options for you or your loved ones struggling with MDMA addiction.

Dose Of MDMA, Effects Of MDMA Overdose

3,4-Methylenedioxymethamphetamine (MDMA, “Molly”, “Ecstasy”) is an amphetamine derivative that has become increasingly popular as a recreational drug in recent years. Part of its popularity may lie in the belief that any dosage of Molly or MDMA is relatively harmless. The use or dosing of MDMA makes people feel euphoric, loquacious, and closer to other individuals; some call it the “love drug.”

Molly dosage is often taken at “house parties” as a mood enhancer. It has, however, many adverse effects, such as loss of appetite, trismus or bruxism (grinding of the teeth), nausea, muscle aches or stiffness, ataxia (poor muscle control), sweating, tachycardia (a heart rate over 100 beats a minute), and hypertension (high blood pressure).

MDMA dosing is also known to damage brain serotonin neurons. There has been a recent increase in cases of severe toxicity following the recreational misuse of relatively small dosages of MDMA (1 or 2 tablets). Complications have included fulminant hyperthermia, convulsions, disseminated intravascular coagulation, rhabdomyolysis, acute renal failure, cardiac arrhythmias, hepatitis, and even liver failure.

Is Molly Safe? Ecstasy Dosing Leading To Overdose

In fatal cases of molly dosing, death is usually due to severe hyperthermia (heatstroke) accompanied by disseminated intravascular coagulation, rhabdomyolysis, and acute renal failure. It is suggested that the combination of the MDMA dose and the circumstances in which it is taken are important in the mechanism of its toxicity.

Most of the serious cases were among people at crowded parties or clubs. At such venues, sustained physical activity (which may itself be an effect of dosing molly), a high ambient temperature, poor ventilation, and inadequate fluid replacement could all reduce heat loss and potentiate a direct effect of the molly dose on thermoregulatory mechanisms, leading to fulminant hyperthermia.

What is the lethal dose of MDMA? There was a report of a 30-year-old man admitted to the Emergency Department of a hospital after being found unconscious, apneic, and with symmetrical convulsions at home. After recovery, he confirmed to have taken 50 tablets of Ecstasy dosage, 10 tablets of oxazepam 10 mg, and 5 units of alcohol over a period of four to five hours. He was intubated d and ventilated and transported to a hospital. On admission, he was still comatose and had convulsions. The symptomatology was an expected manifestation of an Ecstasy dose or amphetamine intoxication.

How Much Is A Molly?

MDMA, more commonly referred to as Ecstasy or molly, is an illegal synthetic drug with characteristics of both a stimulant and a hallucinogen. The singer Miley Cyrus sparked controversy when she released “We Can’t Stop” — a sexy dance anthem, rife with drug references. Though the song’s producer first claimed the lyric was “dancing with Miley,” not “dancing with molly” — which is a slang term for MDMA.

Most MDMA users are teenagers or young adults. More than 10 percent of high school seniors have tried MDMA at least once, and more than 2 percent have used the drug in the past month. MDMA users typically come from middle- and upper-class households. MDMA doses are inexpensive. How much is a point of molly? The average retail price of an MDMA tablet and (ecstasy powder) is between $20 and $30 making it attractive and accessible to younger users.

How much is a dose of MDMA? The cost of molly can vary but it does not tend to fluctuate as wildly as some street drugs. The problem with molly is that people with a molly or MDMA addiction will often take multiple molly doses at a time or within a short time period. The effects and the costs can add up fast.

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MDMA Addiction Statistics

The thought of over twenty thousand MDMA users near death’s door being hauled in by ambulances is certainly troubling. People on psychoactive drugs often come to the hospital because they think something might be wrong; they get scared. With MDMA, a lot of ‘got scared’ stories appear to be happening. Numbers alone don’t really tell the whole story, however: Where things get interesting is not how many users encounter medical problems, but why they do. The distribution of injuries and deaths is not random throughout the user population; it is associated with specific risk factors and behaviors. 


Over ten percent of seniors in high school have used MDMA at least once.

Source: NIH

2.6 million

In 2020, 0.9% (or over 2.6 million) of those 12 and older reported using MDMA (Ecstasy) in the previous 12 months.

Source: NIH


A projected 0.6% of eighth-graders, 0.7% of tenth graders, and 1.1% of twelve-year-old reported using MDMA in the previous year in 2021.

Source: NIH

MDMA Drug Fact Sheet

What is MDMA / Molly / Ecstasy?

MDMA acts as both a stimulant and psychedelic,
producing an energizing effect, distortions in
time and perception, and enhanced enjoyment of
tactile experiences.

Adolescents and young adults use it to reduce
inhibitions and to promote euphoria, feelings of closeness, empathy, and sexuality.

What is its origin?

MDMA is a synthetic chemical made in
labs. Seized MDMA in the U.S. is primarily
manufactured in, and smuggled across U.S.
borders from, clandestine laboratories in Canada
and, to a lesser extent, the Netherlands. A small
number of MDMA clandestine laboratories have
also been identified operating in the U.S.

What are common street names?

Common street names include:

  • Adam
  • Beans
  • Clarity
  • Disco Biscuit
  • E, Ecstasy
  • Eve
  • Go
  • Hug Drug
  • Lover’s Speed
  • Peace
  • STP
  • X
  • XTC

What does it look like?

Molly/MDMA/Ecstasy is mainly distributed in tablet form. MDMA tablets are often sold with logos, creating brand names for users to seek out. The colorful pills are often hidden among colorful candies. MDMA is also distributed in capsules, powder, and liquid forms.

How is MDMA taken?

MDMA use mainly involves swallowing tablets
(50-150 mg), which are sometimes crushed and
snorted, occasionally smoked, but rarely injected.
MDMA is also available as a powder.

MDMA users usually take MDMA by “stacking”
(taking three or more tablets at once) or by
“piggy-backing” (taking a series of tablets over
a short period of time). One trend among young
adults is “candy flipping,” which is the co-abuse of

Molly/MDMA/Ecstasy considered a “party drug. As with many other drugs of abuse, MDMA is rarely use alone. It is common for users to mix MDMA with other substances, such as alcohol and marijuana.

What is its legal status in the United States?

MDMA/Molly/ Ecstasy is a Schedule I drug under the Controlled Substances Act, meaning it has a high potential for abuse, no currently accepted medical use in treatment in the United States, and a lack of accepted safety for use under medical

Is MDMA Addictive?

MDMA can be addictive. A survey of young adult and adolescent MDMA users found that 43 percent of those who reported ecstasy use met the accepted diagnostic criteria for dependence, as evidenced by continued use despite knowledge of physical or psychological harm, withdrawal effects, and tolerance (or diminished response), and 34 percent met the criteria for drug abuse.

Almost 60 percent of people who use MDMA report withdrawal symptoms, including fatigue, loss of appetite, depressed feelings, and trouble concentrating. MDMA affects many of the same neurotransmitter systems in the brain that are targeted by other addictive drugs. Experiments have shown that animals prefer MDMA, much like they do cocaine, over other pleasurable stimuli, another hallmark of most addictive drugs.

The maximal total dose of MDMA was 280 mg. Find out information about the fatal dose of MDMA, its effects, and tips to stay safe.
The maximal total dose of MDMA was 280 mg. Find out information about the fatal dose of MDMA, its effects, and tips to stay safe.
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History Of MDMA

MDMA was developed in Germany in the early 1900s as a parent compound to be used to synthesize other pharmaceuticals. During the 1970s, in the United States, some psychiatrists began using MDMA as a psychotherapeutic tool, even though the drug had never undergone formal clinical trials nor received approval from the U.S. Food and Drug Administration (FDA) for use in humans.

It was only in late 2000 that the FDA approved the first small clinical trial for MDMA that would determine if the drug could be used safely with sessions of ongoing psychotherapy under carefully monitored conditions to treat post-traumatic stress disorder.

Nevertheless, MDMA gained a small following among psychiatrists in the late 1970s and early 1980s, with some even calling it “penicillin for the soul” because it was perceived to enhance communication in patient sessions and reportedly allowed users to achieve insights about their problems.

It was also during this time that MDMA first started becoming available on the street. In 1985, the U.S. Drug Enforcement Administration (DEA) banned the drug, placing it on its list of Schedule I drugs, corresponding to those substances with no proven therapeutic value.

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High dose of MDMA has been linked to cases of serious illnesses and death.
High dose of MDMA has been linked to cases of serious illnesses and death.

How Much Molly To Take?

Of course, giving information on illicit molly dosing is complicated. There is no safe level of illicit drug use. With dangerous drugs comes the need for better quality drug education. Individuals who experiment with drugs put their health and safety at risk. Help prevent MDMA abuse by talking to your loved one about the consequences of using drugs and the importance of making healthy choices.

What is the average dose of MDMA? The average reported normal dosage of MDMA is one to two tablets, with each tablet typically containing between 60 and 120 milligrams of MDMA. It is not uncommon for users to take a second dose of MDMA as the effects of the first dose begin to fade. Its effects last approximately 3 to 6 hours.

How much molly should you take? High doses of MDMA (≥ 3 mg/kg) produced amnesia of fear conditioning memory, some evidence of addictive potential, and antidepressant effects, while low doses of MDMA (≤ 1 mg/kg) did not affect these behaviors.

The present dose-ranging study provides further evidence that 3 mg/kg is the threshold for MDMA-induced amnesia. These findings demonstrate that careful selection of MDMA dose is critical. High dose of MDMA (≥ 3 mg/kg) should likely be avoided due to evidence that they can produce amnesia and molly addiction.

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What Are The Risks Of High Dose MDMA?

High dose of MDMA increases the risk that an individual who has taken low-dose tablets in the past will accidentally take too much of the drug and experience adverse events, including serotonin syndrome, elevated neurotoxicity, and other MDMA overdose symptoms.

However, the baseline risk of MDMA overdose does not increase steadily or predictably as MDMA dosage increases. Your body uses certain enzymes to break MDMA down in your liver. One of the byproducts of MDMA metabolization is known to interfere with a prominent liver enzyme for more than a week after your last dose of MDMA.

This means that the more MDMA you take, the more trouble your body will have processing the drug safely, leading to dramatically different physical and mental effects (including dangerous overdoses) once certain dosage thresholds are passed.

MDMA is an illegal stimulant and hallucinogenic drug.  Higher dose of MDMA can cause stroke and heart attack.
MDMA is an illegal stimulant and hallucinogenic drug. Higher dose of MDMA can cause stroke and heart attack.

MDMA Overdose Effects

MDMA overdose effects include:

  • Agitation
  • Seizures
  • Elevated heart rate or abnormal heart rhythms (tachycardia, arrhythmia)
  • Elevated body temperature (hyperthermia)
  • Hypertension (high blood pressure)
  • Hallucinations
  • Nausea and vomiting
  • Loss of consciousness

Fatal MDMA Overdoses

Death due to MDMA overdose is most common after redosing or if it is taken with other drugs and/or alcohol. Death may occur due to:

  • Liver failure
  • Dehydration
  • Heatstroke
  • Heart attack (cardiac arrest)
  • water intoxication (SIADH)

If you suspect an individual has overdosed on MDMA or any other substance, immediately contact emergency medical services.

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MDMA Addiction Treatment

First and foremost, if you think a loved one is abusing MDMA, you should research the substances and their associated addiction to understand better what your loved one needs.  Next, you must plan an intervention to provide your loved ones with options to battle the effects of MDMA addiction in a safe and supportive environment. During this intervention, offer compassion and support instead of judgment. Lastly, show your support throughout the entire treatment process.

In addition, prolonged drug use can have severe physical and psychological effects on you, so it is essential to seek treatment as soon as possible. Inpatient drug rehab offers intensive care that can help you promptly get through the early stages of withdrawal. 

MDMA Detox

Medical detox is often considered the first stage of treatment. It will help you navigate the complicated withdrawal symptoms but doesn’t address patterns of thought and behavior contributing to drug use. Various treatment approaches and settings can help provide the ongoing support necessary to maintain long-term sobriety after you complete the MDMA detox.

Cravings are very common during drug detox and can be challenging to overcome. This often leads to relapse. Constant medical care provided during inpatient treatment helps prevent relapse. Clinicians can give medication and medical expertise to lessen cravings and withdrawal symptoms.

Inpatient MDMA Addiction Rehab

There isn’t one treatment approach or style that will suit everyone. Treatment should speak to the needs of the individual. Inpatient rehab and addiction treatment aren’t just about drug use. the goal is to help the patient stop using MDMA and other substances, but drug rehab should also focus on the whole person’s needs.

Addiction is a complex but treatable disease that affects brain function and behavior. When someone or their family is considering different treatment facilities, they should account for the complexity of addiction and the needs of the individual. The objective of attending an inpatient rehab center for addiction treatment is to stop using the drug and re-learn how to live a productive life without it.

Following a full medical detox, most people benefit from inpatient rehab. Inpatient drug rehab can last anywhere from 28 days to several months. Patients stay overnight in the rehab facility and participate in intensive treatment programs and therapy. Once someone completes rehab, their addiction treatment team will create an aftercare plan, which may include continuing therapy and participation in a 12-step program like Narcotics Anonymous.


Many rehab programs will also have early morning classes or programs. Group sessions occur during inpatient rehab, as do individual therapy sessions. Family therapy may be part of inpatient rehab when it’s feasible. Alternative forms of therapy may be introduced during inpatient rehab, like a holistic therapy program, yoga for addiction recovery, or an addiction treatment massage therapy.

Several different modalities of psychotherapy have been used in the treatment of mental health disorders along with addiction, including:

  • Cognitive Behavioral Therapy (CBT) – is an effective treatment that involves changing both the patterns of negative thoughts and the behavioral routines which are affecting the daily life of the depressed person for various forms of depression.
  • Dialectical Behavioral Therapy – is a comprehensive mental health and substance abuse treatment program whose ultimate goal is to aid patients in their efforts to build a life worth living. The main goal of DBT is to help a person develop what is referred to as a “clear mind.” 
  • Solution-focused therapy is an approach interested in solutions that can be quickly implemented with a simple first step leading to further positive consequences.
Repeated dose of MDMA is known to produce neurotoxic effects on brain serotonin.
Repeated dose of MDMA is known to produce neurotoxic effects on brain serotonin.

Dual Diagnosis Treatment

Drug abuse and mental health disorders often co-occur. Traumatic experiences can often result in mental health disorders and substance abuse. Dual-diagnosis rehabilitation treats both of these issues together. The best approach for the treatment of dual diagnosis is an integrated system. This strategy treats both the substance abuse problem and the mental disorder simultaneously. Regardless of which diagnosis (mental health or substance abuse problem) came first, long-term recovery will depend mainly on the treatment for both diseases done by the same team or provider.

MDMA Addiction Rehab Near Me

Please, do not try to detox on your own. The detox process can be painful and difficult without medical assistance. However, getting through the detox process is crucial for continued treatment. We Level Up provide proper care with round-the-clock medical staff to assist your recovery through our opioid addiction treatment program medically. So, reclaim your life, and call us to speak with one of our treatment specialists. Our counselors know what you are going through and will answer any of your questions.

MDMA addiction is a condition that can cause major health problems, such as an overdose. We Level Up NJ rehab treatment & detox center can provide you, or someone you love, the tools to recover from this with professional and safe treatment. Feel free to call us to speak with one of our counselors. We can inform you about this condition and clarify issues like withdrawal symptoms. Our specialists know what you are going through. Please know that each call is private and confidential.

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