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By We Level Up NJ Treatment Center | Editor Yamilla Francese | Clinically Reviewed By Lauren Barry, LMFT, MCAP, QS, Director of Quality Assurance | Editorial Policy | Research Policy | Last Updated: April 7, 2023

Is Tizanidine Addictive?

Tizanidine is a medication prescribed to patients who suffer from muscle spasms due to conditions such as multiple sclerosis, an injury to the spinal cord, or other neurological disorders. The muscles are allowed to relax, and there is a reduction in the number of excessive muscle contractions. Although it is not considered a high potential for abuse and is not categorized as a controlled substance, some people are curious whether tizanidine can become addictive.

Is Tizanidine Addictive? When taken exactly as directed by a qualified medical professional, tizanidine is not known to have addictive potential. It does not produce the same euphoric high typically associated with addictive drugs like opioids or stimulants. This is because it does not contain any of those substances. However, due to the sedative properties of tizanidine, there is a possibility that some users will develop a psychological dependence on the substance.

Someone can experience withdrawal symptoms if they suddenly stop taking Tizanidine after long-term use, particularly if they have been taking doses higher than recommended. Anxiety, tremors, high blood pressure, a racing heart rate, and muscle stiffness are all potential withdrawal symptoms. Because of this, it is essential to wean yourself off the medication in a controlled manner under the supervision of a medical professional.

It is essential to keep in mind that tizanidine can affect the way other substances, such as alcohol, work in the body, which can increase the likelihood of unwanted side effects. Combining Tizanidine with alcohol or other substances that affect the central nervous system can result in the development of adverse side effects as well as complications that could pose a threat to the user’s life.

What is Tizanidine Addiction

Tizanidine addiction refers to developing a psychological or physical dependence on the medication Tizanidine. Tizanidine is a muscle relaxant medication typically prescribed to alleviate muscle spasms and associated pain caused by multiple sclerosis, spinal cord injury, or other neurological disorders.

Can You Get Addicted to Tizanidine?

Are Tizanidine addictive? While Tizanidine is not considered to be a highly addictive substance, it has the potential to be abused or misused due to its sedative effects. It works by acting on the central nervous system and suppressing nerve impulses that cause muscle spasms, resulting in feelings of relaxation and drowsiness. Individuals who abuse Tizanidine may take higher doses than prescribed or use the medication in ways other than intended, such as crushing and snorting the tablets to achieve a more intense and immediate effect.

Over time, repeated Tizanidine use can lead to the development of tolerance, where the body requires higher doses of the drug to achieve the desired effects. Dependence can also develop with prolonged use, where the individual experiences withdrawal symptoms if they abruptly stop taking the medication or significantly reduce their dose. In severe cases, Tizanidine addiction can lead to physical and psychological dependence, making quitting challenging without professional help.

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Tizanidine Addiction Statistics

There is limited research on the prevalence of tizanidine addiction, as it is not a commonly abused drug. However, data on prescription drug abuse and addiction may provide some insights.

According to the National Survey on Drug Use and Health, in 2020, an estimated 14.5 million Americans aged 12 or older had misused prescription drugs, including muscle relaxants like Tizanidine, in the past year. This represents approximately 5.4% of the population in this age group.

14.5 Million

Americans aged 12 or older misusing prescription drugs, including muscle relaxants like Tizanidine.

Source: NIDA

20 to 36mg

 Addiction happens when this is the daily average dose of an individual

Source: CDC


Represents approximately 5.4% of the population in this age group.

Source: NIDA

Tizanidine Drug Facts


Common brands: Comfort Pac-tizanidine, Zanaflex

Muscle relaxant

It can treat muscle spasms.

Brand names: Comfort Pac-tizanidine and Zanaflex

Prescription needed

Pregnancy: Consult a doctor

Alcohol: Avoid. Very serious interactions can occur when drinking alcohol while taking Tizanidine.

Tizanidine Effects

What side effects can this medication cause?

  • Dizziness.
  • Drowsiness.
  • weakness.
  • nervousness.
  • depression.
  • vomiting.
  • tingling sensation in the arms, legs, hands, and feet.
  • dry mouth.

Tizanidine Warnings

What medications should not be taken with tizanidine?

Using tizanidine with the following drugs can cause excessive sedation (drowsiness): benzodiazepines such as alprazolam, lorazepam, or diazepam. opioids such as morphine, methadone, or oxycodone. certain antidepressants such as amitriptyline, nortriptyline, or protriptyline.

Tizanidine Warnings

Common side effects of tizanidine include dry mouth, drowsiness, fatigue, and dizziness. The main warnings associated with the drug are the risk of low blood pressure and liver damage.

Who should not take Tizanidine?

You shouldn’t take tizanidine (Zanaflex) if you take either fluvoxamine or ciprofloxacin medications. The combination of these medications can cause dangerous side effects such as low blood pressure. Dizziness effects from tizanidine (Zanaflex) use can also occur when you stand up too fast, especially if you’ve been lying down.

  1. Is muscle relaxer Tizanidine addictive?

    Tizanidine can be addictive, particularly when used for an extended period or at higher than prescribed doses. Tizanidine addiction potential is primarily due to its sedative and calming effects, which can induce euphoria or relaxation.

  2. Is Tizanidine HCL addictive?

    Tizanidine HCl is a muscle relaxant that can be addictive if misused or taken in larger doses than prescribed. Like other muscle relaxants and central nervous system depressants, Tizanidine HCl can lead to physical dependence, tolerance, and addiction if used regularly and for a prolonged period.

  3. Is Tizanidine 4 mg addictive?

    Tizanidine 4 mg can still be addictive if misused or taken in larger doses than prescribed.

Tizanidine Addiction Symptoms

Is Tizanidine addictive? The symptoms of Tizanidine addiction can vary depending on the individual and the severity of the addiction. Some common symptoms of Tizanidine addiction may include the following:

  • Cravings: A strong desire to use Tizanidine, even when unnecessary.
  • Tolerance: The need to take increasing amounts of Tizanidine to achieve the desired effect.
  • Dependence: A physical or psychological reliance on Tizanidine.
  • Withdrawal symptoms: When an addicted person stops using Tizanidine, they may experience withdrawal symptoms, such as anxiety, restlessness, insomnia, muscle pain, and seizures.
  • Neglecting responsibilities: An addicted person may neglect their work, school, or personal responsibilities to obtain and use Tizanidine.
  • Social isolation: An addicted person may avoid social situations or lose interest in activities they once enjoyed.
  • Continuing to use despite negative consequences: An addicted person may continue to use Tizanidine, even if it is causing negative consequences in their life, such as legal problems or relationship issues.

Remember that these Tizanidine addiction symptoms may also be present in individuals who are not addicted to Tizanidine but are taking it as prescribed. It is essential to use Tizanidine only as directed by a healthcare professional to avoid the risk of addiction.

Tizanidine can become addictive if not used properly or taken in higher doses than recommended. Like other drugs that relax muscles and slow down activity in the central nervous system, Tizanidine can cause physical dependence, tolerance, and addiction if used frequently and for an extended period.
Tizanidine can become addictive if not used properly or taken in higher doses than recommended. Like other drugs that relax muscles and slow down activity in the central nervous system, Tizanidine can cause physical dependence, tolerance, and addiction if used frequently and for an extended period.
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Can Tizanidine be addictive? Tizanidine can lead to physical dependence, tolerance, and addiction.
Can Tizanidine be addictive? Tizanidine can lead to physical dependence, tolerance, and addiction.

Tizanidine Addiction Withdrawal Symptoms

Can you become addicted to Tizanidine? Here are some potential Tizanidine addiction withdrawal symptoms:

  • Anxiety and panic attacks
  • Insomnia.
  • Sweating.
  • Headaches.
  • Nausea and vomiting.
  • Diarrhea.
  • Muscle pain and stiffness.
  • Tremors or seizures.
  • Rapid heartbeat.

Not everyone will experience all of these symptoms. The severity and duration of Tizanidine Addiction withdrawal can vary depending on factors such as the individual’s dosage and duration of Tizanidine use, as well as their overall health and medical history. It’s crucial to seek medical supervision and support when discontinuing Tizanidine or any other medication to ensure a safe and successful withdrawal process.

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Tizanidine Addiction Treatment 

Using prescription medications like Tizanidine can be helpful for individuals with muscle spasms and other related conditions. However, misusing Tizanidine by taking larger doses than prescribed can lead to addiction and harmful health effects.

Similarly, individuals with muscle spasm conditions may use other drugs as a form of self-medication to alleviate their symptoms. But prolonged use of these drugs, including Tizanidine, can result in addiction and harm mental and physical health.

Those who struggle with substance abuse disorders and co-occurring conditions require a comprehensive assessment to identify their symptoms accurately. A combination of psychotherapy, medication, and lifestyle changes may be necessary to manage the conditions effectively. To avoid further health complications, seeking professional help is crucial in treating Tizanidine addiction.

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Tizanidine Addiction Medically Assisted Detox

Medical detox is the initial phase of treating drug addiction and typically involves managing withdrawal. However, it doesn’t address the underlying behavior and thought patterns contributing to substance abuse. To achieve long-term recovery, receiving ongoing support from various treatment approaches and settings beyond detox is important.

During detox, experiencing cravings is a frequent occurrence that can increase the risk of relapse. Inpatient treatment with constant medical care can help prevent relapse by providing the necessary medication and medical expertise to mitigate cravings and withdrawal symptoms. Clinicians can also offer guidance and support to help individuals manage their addiction and maintain sobriety.

Tizanidine is it addictive? Tizanidine, also known as Zanaflex, is a muscle relaxant medication that can be addictive if misused or taken in larger doses than prescribed.
Tizanidine is it addictive? Tizanidine, also known as Zanaflex, is a muscle relaxant medication that can be addictive if misused or taken in larger doses than prescribed.

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Suffering from Tizanidine Addiction? Call us so we can help right away!
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Tizanidine and Alcoholism Treatment

Alcohol and muscle relaxants combined form co-occurring substance abuse. Substance abuse requires the strongest treatment possible: specialized addiction treatment. A credible treatment program will begin with medical detox, during which the body is cleansed of alcohol and tizanidine, and the withdrawal symptoms are managed with safe medications. You will have a medical evaluation to determine whether you require any medical attention, and you will be monitored closely to ensure a secure and safe detox.

When used with alcohol, tizanidine poses a serious risk of death and can have negative side effects. The detox process from prescription medications can be difficult and painful without medical assistance. However, detox is a necessity for continuing treatment. We Level Up NJ provides the necessary care to aid you through our medication-assisted treatment program, with a 24-hour medical team on call. Call us if you’d like to talk with one of our counseling experts. Our therapists will answer your questions as they are aware of your situation.

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