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How Long Does Molly Last? Withdrawal Side Effects, Risks, & Treatment Options

The side effects of Molly can be extremely dangerous without treatment. Discover the dangerous Molly side effects, withdrawal symptoms, and treatment options available to those suffering from addiction.

By We Level Up NJ Treatment Center | Editor Yamilla Francese | Clinically Reviewed By Lauren Barry, LMFT, MCAP, QS, Director of Quality Assurance | Editorial Policy | Research Policy | Last Updated: February 1, 2023

How Long Does Molly Last?

The effects of MDMA (Molly) can last up to six hours. Typically, the peak effects are experienced two hours after taking MDMA, and the drug typically starts to wear off after four hours. The effects of MDMA can vary greatly depending on the individual user, as well as how much of the drug is taken. Some people experience a lasting euphoria after the initial peak. Other short-term effects include increased energy and sociability, emotional openness, and decreased inhibition. However, it’s important to keep in mind that MDMA can also lead to adverse effects, such as anxiety, confusion, paranoia, and muscle tension.

Continue reading to learn how long does Molly last in your system factors.

How Long Does Molly Last In Your System?

Molly is the street name for the drug MDMA, which is a psychoactive substance that is often taken in the form of a pill or capsule.

Generally, Molly stays in a person’s system for several days. Molly enters the bloodstream very quickly after you use it. However, even after its effects wear off, traces of the drug will stay in your system. Molly may stay in your system for up to five days. Since tolerance also increases with use, if you use Molly chronically, it may be detectable in your system for up to a week after your last use. Higher doses may be detectable in your system for longer. Although it’s not one of the five drugs tested by the standard five-panel drug test most employers use, molly can show up on a drug test.

How long does Molly last in system? Detection times for how long ecstasy lasts in your system:

  • Blood: An MDMA (molly) drug test can detect molly in the blood for 1 to 2 days after it’s taken.
  • Urine: Ecstasy (molly) can be detected in urine for 2 to 4 days after it’s taken.
  • Hair: Like other drugs, molly can be detected in hair follicles for several months.

The way it’s used also affects how long molly/MDMA stays in your system and its detection window. The faster it’s absorbed into the bloodstream, the shorter the detection window. For instance, when compared to oral ingestion, molly will stay in the body for a shorter amount of time when it’s snorted.

Most people have heard of the drug ecstasy, which is also known as MDMA, short for 3,4-methylenedioxymethamphetamine [1] which is grown synthetically in a lab. Ecstasy rose in popularity in nightclubs during the 1980s and 1990s. The pills gave users the euphoric high of amphetamines and the psychedelic effects of hallucinogens. Molly contains MDMA in a crystalline powder contained in a capsule. It’s a concentrated form of ecstasy, but users don’t always know if it’s truly “pure.” Like all synthetic drugs, it could be diluted with other psychogenic substances.

Molly is short for “molecule”. Any drug that is purchased on the street is always subject to being named something different. According to the National Institute for Drug Abuse (NIDA). An estimated 11 million Americans have used ecstasy at least once in their lives. The drug can be adulterated with other chemicals like bath salts, a relatively new synthetic powder that often contains amphetamine-like chemicals.

MDMA is a Schedule I controlled substance. This indicates the Drug Enforcement Administration (DEA) recognizes it as having no medical use and a high potential for misuse or addiction. As a result, it’s illegal to sell, buy, or use any form of MDMA — including molly — in the United States. There are also potent designer cathinone stimulants known by the street name “bath salts,” often marketed as molly. People taking these substitutes have solid cravings and much more violent reactions.

How Is MDMA Used?

Most MDMA users take it as a pill or tablet, however, some inhale the powder or ingest it as a liquid. The widely used nickname Molly, which is shorthand for “molecular,” frequently alludes to the supposedly “pure” crystalline powder form of MDMA, which is typically supplied in capsules. However, when consumers buy powder or capsules marketed as Molly, they frequently end up with other substances like synthetic cathinones (also known as “bath salts”) instead.

Some people combine MDMA use with the use of other substances, such as alcohol or marijuana.

Molly Addiction Statistics

Nightclubs and festivals are popular places for this drug’s use, especially among young people. For the 2014 Global Drugs Survey, nearly 80,000 young individuals who use drugs globally were polled. In this sample, MDMA was among the top five substances consumed in the previous year, with more than 50% of participants claiming to go “clubbing” at least four times annually. More than 20% of respondents from the United States said they had used MDMA in the previous year.


Over ten percent of seniors in high school have used MDMA at least once.

Source: University of
Michigan’s Monitoring the Future

2.6 million

In 2020, 0.9% (or over 2.6 million) of those 12 and older reported using MDMA (Ecstasy) in the previous 12 months.

Source: NIH


A projected 0.6% of eighth-graders, 0.7% of tenth-graders, and 1.1% of twelve-year-olds reported using MDMA in the previous year in 2021.

Source: NIH

How Does MDMA Affect The Brain?

Three brain molecules are activated more by MDMA, which are:

  • Dopamine– increases activity and energy and works with the reward system to reinforce behaviors.
  • Norepinephrine– elevates blood pressure and heart rate, which are dangerous for those who already have heart and blood vessel issues.
  • Serotonin– influences various functions, including mood, hunger, and sleep. Additionally, it releases chemicals that influence trust and sexual arousal. People who use MDMA likely experience emotional intimacy, improved mood, and empathy because of the significant serotonin release.

Other negative health impacts include:

  • nausea
  • muscle cramping
  • uncontrollable clenching of the teeth
  • blurred vision
  • chills
  • sweating

Although many users take a second dose as the effects of the first dose start to wear off, the effects of MDMA last for roughly 3 to 6 hours. A person who uses the substance moderately for a week may go through the following:

  • irritability
  • impulsivity and hostility
  • depression
  • issues with sleep
  • anxiety
  • issues with concentration and memory
  • decreased appetite
  • decreased interest in and pleasure from sex

Some of these symptoms might result from mixing MDMA with other drugs, particularly marijuana.

People who use MDMA usually take it as a capsule or tablet, though some swallow it in liquid form or snort the powder. 
People who use MDMA usually take it as a capsule or tablet, though some swallow it in liquid form or snort the powder.  How long does molly last? Most report up to several days, read on for more details.
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How Long Does Molly Stay In Your Urine

The length of time that MDMA can be detected in the urine depends on a variety of factors, including the dose taken, the individual’s metabolism, and the sensitivity of the drug test being used.

In general, MDMA can be detected in the urine for 1-3 days after use. However, it is possible for the drug to be detected for longer periods of time in some individuals. For example, heavy users of MDMA may test positive for the drug for up to a week after their last use.

It’s important to note that the detection times for drugs can vary widely, and the above estimates are only general guidelines. The only way to know for sure how long a particular drug will be detectable in an individual’s urine is to test the sample using a drug testing kit.

Molly/Ecstasy/MDMA PDF

Health Effects Of MDMA

MDMA in high amounts can interfere with the body’s capacity to control temperature. This can cause a rise in body temperature, which on rare occasions can cause heart, liver, or renal failure as well as death.

Additionally, the use of MDMA, especially when taken with sildenafil (Viagra), may encourage risky sexual conduct since it can foster closeness and trust. People are now more likely to get or spread hepatitis or HIV as a result of this.

Risks Of MDMA

The possibility of other drugs being present in pills, capsules, or powders marketed as Ecstasy or Molly that are supposed to be “pure” adds to the dangers of MDMA. Coke, ketamine, methamphetamine, over-the-counter cough medicine, and synthetic cathinones are among the additions found in a large portion of the Molly that police have confiscated (“bath salts”). If a person does not know what he or she is taking, these substances may be quite dangerous. Together with MDMA, they could be harmful. People who intentionally or accidentally mix this substance with others, such as alcohol, and marijuana, may increase their risk for negative health effects.

How Long Does Molly Effects Last?

The main effects of Molly last around 3 hours, and minor effects last around 7 hours – assuming your substance contains pure MDMA.

If you’re a new user taking Molly on an empty or mostly empty stomach, you should notice the Molly kick in around 1 hour after ingestion – experienced users who are familiar with the effects may notice it kick in after as little as 30 minutes.

The primary effects of Molly last for about 3 hours, generally from hours 1 to 4 after ingestion. You will likely feel some effects for about 7 hours, from roughly 30 minutes after ingestion until around 7-8 hours after ingestion.

A substantial portion of Molly/Ecstasy sold as MDMA isn’t really MDMA, and so if you’re experiencing different timing than described here, you may not have real MDMA.

How long does Molly last in the human body and what are the after-effects of using Molly are questions that many misusers of the drug may have.
 How long does molly last In your system? How long does Molly last in the human body and what are the after-effects of using Molly are questions that many misusers of the drug may have.

Over the course of the week following moderate use of the drug, a person may experience:

  • Irritability
  • Impulsiveness and aggression
  • Depression
  • Sleep problems
  • Anxiety
  • Memory and attention problems
  • Decreased appetite
  • Decreased interest in and pleasure from sex

It’s possible that some of these effects may be due to the combined use of MDMA with other drugs, especially marijuana.

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Factors That Affect How Long Molly Is In Your System

There are plenty of other factors that can also influence how long molly stays in your system, including how much of it is taken, how often it’s taken, and the individual’s metabolism.

  • Dosage and frequency of use: When taken in larger doses or multiple doses are taken over time, MDMA can last longer in the body. Similarly, first-time users may have a shorter detection window for ecstasy than long-time users.
  • Body type: Many drugs tend to build up in fatty tissue, meaning that people with a high body mass index (BMI) or more body fat may take longer to eliminate the drug from their systems.
  • Metabolism: A person’s metabolism can be affected by age, level of physical activity, and other health conditions. The higher the metabolism, the shorter the detection window for ecstasy.
  • Other health concerns: Other underlying health conditions such as liver and kidney disease can also impact how quickly a person metabolizes MDMA. Because these two organs are mainly responsible for flushing toxins out of the body, a person with conditions in these areas may struggle to metabolize molly.

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Is MDMA Addictive?

According to various studies, MDMA may be addictive. Animals will self-administer MDMA in experiments, but less frequently than with other drugs like cocaine, which is a crucial sign of a drug’s misuse potential.

Some people describe withdrawal symptoms like those listed below:

  • fatigue
  • appetite loss
  • depression
  • difficulty focusing

MDMA Therapy

In the 1970s, MDMA was first utilized as a tool in psychotherapy (mental disorder treatment using “talk therapy”). The medication lacked support from human studies (clinical trials) and US Food and Drug Administration approval (FDA). The United States Drug Enforcement Administration (DEA) classified MDMA as an illicit substance without a valid medical justification in 1985. However, when administered to patients under precisely controlled circumstances, several researchers are nonetheless intrigued by its potential in psychotherapy. Clinical trials are currently being conducted on MDMA as a potential treatment for PTSD, anxiety in terminally ill patients, and social anxiety in adults with autism. MDMA-assisted psychotherapy for PTSD recently received the FDA’s Breakthrough Therapy designation.

Molly Withdrawal

Molly is extremely psychologically addictive and those addicted to molly will experience withdrawal when they quit using the drug. Withdrawal happens because the user’s brain becomes dependent on ecstasy to function.

Taking molly increases the activity of neurotransmitters—specifically those that influence feelings of happiness and love—in the brain. This causes the euphoric high and positive emotions associated with using molly. However, this increase in activity also quickly depletes the brain’s supply of the chemicals needed to feel this way.

After prolonged use, the user’s brain can become dependent on molly to function and experience these positive feelings. When someone quits taking the drug, they’ll go through withdrawal as their brain tries to relearn how to operate properly without it. During withdrawal, users typically experience the opposite of what they felt while high, like depression and anxiety, and they’ll also intensely crave the drug.

The symptoms of molly withdrawal tend to be primarily psychological, but some users experience physical effects as well. The symptoms and duration of withdrawal vary by person. Some of the things that affect the withdrawal process include:

  • Tolerance
  • The frequency and duration of drug use
  • Metabolism and overall health
  • Age
  • Gender
  • Genetics

A user who has multiple addictions may also have a more intense and complicated withdrawal, and a user who has co-occurring mental health disorders may also experience additional challenges.

Molly Withdrawal Symptoms

Withdrawal from molly can produce serious psychological symptoms and some users may experience physical discomfort. However, the physical effects are typically mild and not life-threatening. Molly withdrawal symptoms may include:

  • Depression
  • Confusion
  • Anxiety
  • Cravings
  • Agitation
  • Paranoia
  • Insomnia
  • Fatigue
  • Difficulty concentrating
  • Loss of appetite
  • Memory problems
  • Changes in self-perception

Molly is often cut with other drugs, such as heroin, ketamine, amphetamines, and other illicit drugs. In many cases, molly is also taken alongside other drugs, such as cocaine or LSD. Because it’s hard to know what’s in a pill of ecstasy and so many users tend to combine it with other drugs, withdrawal symptoms are often different for each person.

Relapse during the molly withdrawal process is especially dangerous because the user’s tolerance has decreased. If they jump back into using the same amount of molly, they’re at an increased risk of overdose—which can be fatal.

Managing the symptoms of withdrawal from molly—especially the feelings of depression, which are often severe—can be difficult for a person to do on their own. It is recommended that users complete the withdrawal process in a medical detox facility or an inpatient rehab.

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  1. How Long Does A Molly High Last?

    If you are wondering, “how long does molly high last? or how long does a molly trip last “, the answer is that an average Molly high lasts between three and six hours.

  2. How Long Does Molly Last For?

    If you are wondering, “how long does molly trip last? or how long does a molly comedown last?”, the answer is that it often lingers in the body of a person for several days. The precise period of time varies on a number of variables, including the individual’s metabolism and the dosage of the drug they have consumed.

  3. How Long Does Molly Withdrawal Last?

    If you are wondering, “how long does molly come down last? or how long does molly comedown last?”, the answer is due to the many variables involved in tapering off MDMA, it can be challenging to determine a precise timeline for molly withdrawal. The intensity and duration of withdrawal symptoms can be significantly influenced by the use of other drugs, duration of usage, dose consumed, the presence of any adulterants in the marijuana, and any underlying medical or mental health conditions.

  4. How Long Does A Molly Hangover Last?

    If you are wondering, “how long does the effects of molly last?”, the answer is that for the majority of people, the drug will be sufficiently digested and the effects will have started to wear off within 10 to 24 hours. Within a short time, the person will gradually start to feel better as the ensuing neurotransmitter depletion steadily reverses.

  5. How Long Does Molly Depression Last?

    A person’s serotonin levels may sharply decline during a comedown. Depression and thoughts of suicide may develop as a result of this abrupt decline. In particular, for people who have a history of depression or other mental health disorders, MDMA dependence may eventually result in long-term abnormalities in brain chemistry. Additionally, MDMA users who concurrently use alcohol, marijuana, or any other drugs may be more susceptible to developing depression after use.

  6. How Long Does Molly Last In Urine?

    Up to three days after administration, Molly can still be found in urine. When MDMA enters the bloodstream, it is transported to the liver, where it is metabolized and eliminated. A half-hour after consuming molly, if you take a big dose, it can show up in your urine.

  7. How long does molly last In your system for men vs women?

    The duration of MDMA in the system does not differ significantly between men and women. Generally, the half-life of MDMA is about 9 hours for both men and women. However, due to the great variability in body composition, weight, and metabolism, the duration can differ from person to person. Thus, The duration of MDMA in the system does not differ significantly between men and women. Generally, the half-life of MDMA is about 9 hours for both men and women. However, due to the great variability in body composition, weight, and metabolism, the duration can differ from person to person.

  8. How long does molly last In your system adults vs teens?

    In adults, the half-life of molly (MDMA) is about 9 hours, and it is similar for both adults and teens. However, the duration may vary from person to person due to differences in body composition, weight, and metabolism.

    Thus, the age-based slower metabolism of older adults will likely account for a longer response time to how long does molly last In your system.

  9. How long does molly last In your system in combination with alcohol?

    When molly is combined with alcohol, its effects do not last as long due to the faster metabolization of alcohol. Generally, the effects of molly will last for about 4 to 8 hours in combination with alcohol.

  10. How long does molly last In your system in combination with other drugs?

    The length of time that molly will last in combination with other drugs will depend on the type of drug and its metabolism. However, it is generally safe to assume that the effects of molly will last for approximately 4 to 8 hours.

Molly Addiction Treatment

How long does molly last In your system and is addiction treatment required for heavy abuse of MDMA? Molly typically remains in the system for up to 72 hours, depending on one’s metabolism. In terms of addiction treatment, the length of time for molly to be eliminated from the body can vary greatly depending on how long one has been using and the severity of the addiction.

Medical detox offers the safest and most effective means of withdrawal. It provides a stable and safe environment where molly can process out of the body while helping the individual reach a physical and psychological level of stability before continuing on in treatment.

Withdrawal from molly is not typically considered to be physically life-threatening as withdrawal from other drugs and alcohol may be. However, this is not to say that the side effects may not be intense and significant. Anxiety, insomnia, and depression can be particularly difficult, and a medical detox program can help to manage these symptoms of ecstasy withdrawal.

In a medical detox program, individuals are admitted to a specialized facility that provides medical and mental healthcare and supervision 24 hours a day, seven days a week. The environment is calm and secure, and individuals are encouraged and supported around the clock. Relapse and cravings can be minimized through supportive care and therapeutic methods.

Currently, there are no specific medications approved to treat molly dependence or withdrawal. However, different pharmacological tools may be helpful in managing specific symptoms. For instance, sleep aids may help to combat insomnia, and this can be essential as a healthy amount of sleep enhances healing. In a similar fashion, antidepressant medications may help to replenish serotonin and/or dopamine levels in order to manage depression and anxiety.

Individuals who have abused ecstasy on a long-term basis often suffer from lost appetite, malnutrition, and even possible weight loss or anorexia. Nutritional deficits can be rectified via regular, healthy, and balanced meals that are provided in a professional detox program.

Dehydration can be a result of ecstasy abuse, and this can be addressed with increased fluids during detox. When a person is well-rested and nutritionally balanced, they are more able to think clearly and make better decisions; thus, they are better equipped to avoid relapse.

Medical detox programs generally last 5-7 days. While they are an essential component of recovery, further treatment is needed. Ideally, clients progress directly from medical detox into a comprehensive addiction treatment program.

How long does Molly last in the human body and what are the after-effects of using Molly are questions that many misusers of the drug may have. If you feel that you may have developed a substance use disorder involving Molly/Ecstasy/MMDA, help is available. Contact We Level Up to learn more about addiction treatment today.

How long does molly last In your system? It is difficult to determine exactly how long molly will stay in a person’s system. It depends on many factors. Molly affects the brain by increasing the activity of three brain chemicals: serotonin, dopamine, and norepinephrine.  Moreover, there are multiple factors impacting how long does molly last In your system?
How long does molly last In your system? It is difficult to determine exactly how long molly will stay in a person’s system. It depends on many factors. Molly affects the brain by increasing the activity of three brain chemicals: serotonin, dopamine, and norepinephrine. Moreover, there are multiple factors impacting how long does molly last In your system?

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Search We Level Up How Long Does Molly Last & Other Resources

[1] NIDA –[2] DEA – Learn how long does molly last?

[2] DEA – Background on how long does molly last.

National Institute on Drug Abuse. (2018). MDMA/Ecstasy (Molly).  Facts on how long does molly last.

Scientific American. (n.d.). What are the effects of the drug Ecstasy?  And how long does molly last under long term use.

Center for Substance Abuse Research. (2013). Ecstasy. Research includes how long does molly last.

Kim, J., Fan, B., Liu, X., Kerner, N., & Wu, P. (2011). Ecstasy use and suicidal behavior among adolescents: findings from a national surveySuicide & life-threatening behavior41(4), 435–444. Effects and how long does molly last.

National Institute on Drug Abuse. (2017). MDMA (Ecstasy) Abuse. How long does molly last under heavy dosage.

National Institute on Drug Abuse. (2017). MDMA (Ecstasy) Abuse. How long does molly last summary.

emedicine health. (n.d.). Fever (in Adults).  How long does molly last in adults.

Mayo Clinic. (2018). Hyponatremia. How long does molly last.