By We Level Up NJ Treatment Center | Editor Yamilla Francese | Clinically Reviewed By Lauren Barry, LMFT, MCAP, QS, Director of Quality Assurance | Editorial Policy | Research Policy | Last Updated: April 5, 2023
How Long Does Wellbutrin Stay in Your System?
Wellbutrin (bupropion) is a prescription medication for depression and seasonal affective disorder. It can also be used as a smoking cessation aid.
The length of time that Wellbutrin stays in your system can vary depending on several factors, including your age, weight, dosage, and metabolism.
Here are some general timelines for how long Wellbutrin can stay in your system:
- Blood: Wellbutrin can be detected in blood tests for up to 24 hours after the last dose.
- Urine: Wellbutrin can be detected in urine tests 3-5 days after the last dose.
- Hair: Wellbutrin can be detected in hair tests for up to 90 days after the last dose.
How long for wellbutrin to leave system can be affected by other medications you may be taking and any underlying health conditions you may have. Always speak with your doctor or healthcare provider if you have questions or concerns about how long Wellbutrin may stay in your system.
Does Wellbutrin Show Up on a Drug Test?
You might ask:”Does wellbutrin show up on a urine drug test?” Wellbutrin may appear on a drug test, but it depends on the type of test being used. Standard drug tests such as urine, blood, or saliva tests do not typically screen for Wellbutrin.
However, it is possible for specific Wellbutrin drug tests to detect the presence of Wellbutrin in a person’s system, depending on the type of test being used. How long does wellbutrin stay in your system can vary.
A standard drug test, also known as a 5-panel drug test, does not usually screen for Wellbutrin. Employers, schools, and other organizations typically use this type of test to screen for illegal substances such as marijuana, cocaine, opioids, amphetamines, and PCP.
However, some more comprehensive drug tests, such as a 10-panel drug test, may include bupropion as part of their screening process. This type of test is usually reserved for more specialized situations, such as in medical settings or in cases where there is suspicion of prescription drug misuse.
Even if Wellbutrin show up on drug tests, it is not considered a positive result as it is a prescribed medication and not an illegal substance. Individuals should always disclose any medications they are taking to their healthcare provider and any testing agency to ensure accurate results and appropriate treatment.
How to Get Wellbutrin Out of Your System Fast
First and foremost, consult with a healthcare professional before making any decisions about medication. However, if you are unable or unwilling to see a doctor, there are some steps you can take to help flush Wellbutrin out of your system. These include:
- Drinking plenty of water: Drinking lots of water can help flush out any remaining traces of the medication.
- Exercise: Exercise can help increase metabolism and accelerate the elimination of drugs from the body.
- Eat a healthy diet: Eating a balanced diet with plenty of fruits and vegetables can help support the body’s natural detoxification processes.
- Get plenty of rest: Adequate sleep and rest can help the body repair and regenerate, supporting the elimination of Wellbutrin.
- Avoid drugs and alcohol: Using other substances can interfere with the body’s ability to eliminate drugs, so it’s important to avoid using other drugs or alcohol while trying to flush Wellbutrin out of your system.
It’s important to note that attempting to flush a medication out of your system without medical guidance can be dangerous and should not be attempted without careful consideration and research. It’s always best to speak with a healthcare professional and ask them how to flush Wellbutrin out of your system safely.
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Prescription Abuse Statistics
45.8% of American adults used a prescription drug – legally or not – within the past 30 days. Healthcare specialists generally agree that a high use rate and availability drive reported rates of prescription drug abuse, addiction, and overdose.
People misuse prescriptions a year.
People or 11.9% of people who misuse prescriptions are definitively addicted to the prescription drugs they misuse.
Prescription drug abusers constitute 5.76% of Americans over the age of 12.
Bupropion Drug Facts Sheet
Why is this medication prescribed?
Bupropion (Aplenzin, Wellbutrin, Wellbutrin SR, Wellbutrin XL) is used to treat depression. Bupropion (Aplenzin, Wellbutrin XL) is also used to treat seasonal affective disorder (SAD; episodes of depression that occur at the same time each year [usually in the fall and winter but rarely may occur in the spring or summer months]).
Bupropion (Zyban) is used to help people stop smoking. Bupropion is in a class of medications called antidepressants. It works by increasing certain types of activity in the brain.
How should this medicine be used?
Bupropion comes as a tablet and a sustained-release or extended-release (long-acting) tablet to take by mouth. The regular tablet (Wellbutrin) is usually taken three times a day, with doses at least 6 hours apart, or four times a day, with doses at least 4 hours apart. The sustained-release tablet (Wellbutrin SR, Zyban) is usually taken twice a day, with doses at least 8 hours apart.
The extended-release tablet (Aplenzin, Wellbutrin XL) is usually taken once daily in the morning; doses of the extended-release tablet should be taken at least 24 hours apart.
Other uses for this medicine
Bupropion is also sometimes used to treat episodes of depression in patients with bipolar disorder (manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods) and to treat attention deficit hyperactivity disorder (ADHD; more difficulty focusing, controlling actions, and remaining still or quiet than other people who are the same age).
Talk to your doctor about the possible risks of using this medication for your condition.
Metabolism: Liver, intestines
- Bupropion: 11–21 h
- Hydroxybupropion: 20 h
- Threohydrobupropion: 37 h
- Erythrohydrobupropion: 33 h
- Urine: 87% (0.5% unchanged)
- Feces: 10%
You should not take bupropion if you have seizures or an eating disorder, or if you have suddenly stopped using alcohol, seizure medication, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking.
Do not use bupropion within 14 days before or 14 days after you have used a MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
8 Popular How Long Does Wellbutrin Stay in Your System? FAQs
How long does Wellbutrin XL stay in your system?
How long does wellbutrin stay in your system can vary. On average, Wellbutrin XL can stay in the system for 4-5 days after the last dose. However, this can vary depending on age, weight, liver and kidney function, and dosage. It is important to note that the medication may still show up in urine or blood tests for up to a week after the last dose.
How long does Wellbutrin SR stay in your system?
How long does wellbutrin stay in your system can vary. Wellbutrin SR (sustained-release) is a formulation of bupropion that is designed to release the medication slowly over time, allowing for once or twice-daily dosing.
On average, it takes about 5 half-lives for a drug to be completely eliminated from the body. The half-life of Wellbutrin SR is approximately 21 hours. Therefore, it can take around 5 days (or 120 hours) for Wellbutrin SR to be completely eliminated from your system.
How long does Wellbutrin 150 mg stay in your system?
On average, it takes around 5 half-lives for a medication to be eliminated from the body, meaning that it can take around 7-8 days for Wellbutrin 150 mg to be fully cleared from your system.
However, it’s important to note that individual factors can cause this time frame to vary. For example, if you have liver or kidney disease, it may take longer for Wellbutrin to be eliminated from your system. Additionally, if you take other medications that interact with Wellbutrin, this can also affect how long it stays in your system. How long does wellbutrin stay in your system can vary.
Will Wellbutrin show up on a drug test?
Wellbutrin is not typically included in standard drug tests. However, some specialized drug tests can detect the presence of bupropion, the active ingredient in Wellbutrin. How long does wellbutrin stay in your system can vary.
What does Wellbutrin show up as on a drug test?
It is possible for certain specialized drug tests to detect Wellbutrin or its metabolites in the body. These tests are typically used in situations where the detection of medication use is critical, such as in forensic or workplace drug testing. How long does wellbutrin stay in your system can vary.
How long does Wellbutrin detectable in urine?
how long until wellbutrin is out of your system can depend on several factors, such as the individual’s age, weight, metabolic rate, and the frequency and dosage of the drug. In general, Wellbutrin can be detected in urine for up to five days after the last dose. However, some sources suggest that chronic users can detect it for up to 10 days or more. how long until wellbutrin is out of your system can depend on these factors.
Can Wellbutrin cause a false positive drug test?
While it is uncommon, there have been rare cases of Wellbutrin causing a false positive on a drug test. This is because some drug tests may not be specific enough to distinguish between the metabolites of Wellbutrin and other drugs. However, confirmatory testing can usually identify the true cause of the positive result. It is important to inform the drug testing facility of all medications you are taking, including prescription drugs like Wellbutrin, to avoid any potential issues with false positive results.
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Wellbutrin for Depression
Individuals with depression may experience low levels of dopamine and norepinephrine, and aminoketone medications like Bupropion can increase these levels by blocking the brain’s reabsorption of these chemicals. This can help alleviate symptoms of depression.
When used to treat depression, Wellbutrin (bupropion) typically takes six to eight weeks to work fully. However, some individuals may experience improvements in their sleep habits, appetite, and energy levels as early as one to two weeks into treatment.
The time it takes for Wellbutrin to work for anxiety can vary depending on several factors. For anxiety symptoms associated with depression or smoking cessation, improvements may be noticed within one to two weeks of starting treatment. However, achieving full symptom relief may take up to eight weeks.
- Fatigue: People may feel excessively tired or fatigued during Wellbutrin withdrawal.
- Increased appetite: Some individuals may experience an increase in appetite or weight gain when they stop taking Wellbutrin.
- Suicidal thoughts: Withdrawal from antidepressants, including Wellbutrin, may increase the risk of suicidal thoughts or behaviors, particularly in younger people.
Wellbutrin Withdrawal Symptoms
Wellbutrin is an antidepressant medication that is used to treat depression and seasonal affective disorder and to help people quit smoking. If someone stops taking Wellbutrin suddenly or significantly reduces their dosage, they may experience withdrawal symptoms.
Some common Wellbutrin withdrawal symptoms include:
- Mood changes: People may experience mood swings, irritability, and anxiety when they stop taking Wellbutrin.
- Physical symptoms: Withdrawal from Wellbutrin can cause physical symptoms like headaches, dizziness, nausea, and flu-like symptoms.
- Insomnia: Some people may experience difficulty sleeping or insomnia when withdrawing from Wellbutrin.
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Wellbutrin for Smoking Cessation
Using Wellbutrin as a treatment for smoking cessation can be effective in helping individuals quit smoking. The exact reason why bupropion works as a smoking cessation aid is not fully understood, but it’s believed to be due to its effects on dopamine levels in the brain.
Unlike other smoking cessation treatments, bupropion does not contain nicotine. Instead, it may mimic some of the effects of nicotine, causing the brain to release more dopamine. This can help individuals manage symptoms of nicotine withdrawal and cravings that commonly occur when quitting smoking. While it may not reduce nicotine addiction, it can aid in the quitting process.
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- Dizziness or lightheadedness.
- Insomnia or changes in sleep patterns.
- Tremors or shaking.
- Increased heart rate or palpitations.
- Blurred vision.
- Agitation or irritability.
Wellbutrin Side Effects
Wellbutrin, also known as bupropion, is an antidepressant medication that can be prescribed for a range of mental health conditions. While it is generally considered safe and effective, like any medication, it can cause side effects. Some of the most common side effects associated with Wellbutrin include:
- Dry mouth.
- Nausea and vomiting.
- Constipation or diarrhea.
- Weight loss or gain.
- Changes in appetite.
- Seizures (in rare cases).
It’s important to note that not everyone will experience these side effects; some may experience different side effects not listed here. Some side effects may go away as your body adjusts to the medication, while others may require medical attention. If you experience any concerning or severe side effects while taking Wellbutrin, it’s important to contact your doctor right away.
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Wellbutrin Addiction Treatment
Wellbutrin (bupropion) is a medication that is primarily used to treat depression, and seasonal affective disorder and to aid smoking cessation. Although it is not commonly associated with addiction, individuals can develop a dependence on Wellbutrin, particularly if it is misused or taken in higher doses than prescribed.
If an individual is struggling with Wellbutrin addiction, they should seek professional help from a healthcare provider or addiction specialist. The first step in treating Wellbutrin addiction is to stop taking the medication, which can result in withdrawal symptoms such as headaches, nausea, and irritability.
A healthcare provider may also prescribe medications to manage withdrawal symptoms and provide support during the recovery process.
In addition to medication and therapy, lifestyle changes such as exercise, healthy eating habits, and stress management techniques can also help promote recovery and prevent relapse. It is important to seek professional help and follow a comprehensive treatment plan to overcome addiction to Wellbutrin effectively.
Medically Assisted Detox
Medical detox is the initial phase of treating drug addiction and typically involves managing withdrawal. However, it doesn’t address the underlying behavior and thought patterns contributing to substance abuse. To achieve long-term recovery, receiving ongoing support from various treatment approaches and settings beyond detox is important.
During detox, experiencing cravings is a frequent occurrence that can increase the risk of relapse. Inpatient treatment with constant medical care can help prevent relapse by providing the necessary medication and medical expertise to mitigate cravings and withdrawal symptoms. Clinicians can also offer guidance and support to help individuals manage their addiction and maintain sobriety.
Psychotherapy for Depression and Anxiety
Several different modalities of psychotherapy have been used in the treatment of depression, including:
- Cognitive Behavioral Therapy (CBT) – An evidence-based therapy that is highly effective in treating depression. This therapy helps individuals change negative patterns of thinking and behavior that contribute to their depression. CBT is a structured, short-term therapy that focuses on specific goals and is often used with medication.
- Person-Centered Therapy – A humanistic approach that emphasizes empathy, unconditional positive regard, and authenticity. This therapy aims to create a supportive and non-judgmental environment where individuals can explore their feelings, thoughts, and behaviors.
- Solution-Focused Therapy – a brief therapy that focuses on finding solutions to specific problems. This therapy encourages individuals to identify their strengths and build on them rather than focusing on their weaknesses or problems. Solution-Focused Therapy is often combined with other therapies and can effectively treat mild to moderate depression.
Wellbutrin Dual Diagnosis Treatment
Co-occurring substance abuse and mental health disorders are prevalent, as traumatic experiences can contribute to the development of both. Dual diagnosis rehabilitation is a specialized approach that addresses both issues concurrently, recognizing the complex interplay between mental health and substance abuse. An integrated system of care that treats both disorders simultaneously is often the best approach for effective treatment and recovery.
It is important to note that treating one disorder without addressing the other can result in poor outcomes, as both disorders often reinforce and perpetuate each other. Whether the mental health disorder or substance abuse problem came first, the same team or provider should handle the treatment for both disorders to ensure that all underlying issues are addressed.
Dual diagnosis treatment may include a combination of evidence-based therapies, medication management, and ongoing support to promote long-term recovery. It can be challenging, but seeking professional help is essential to healing and a better quality of life.
Wellbutrin Medication-Assisted Treatments
Medication-Assisted Treatments (MAT) are a common approach in rehab centers to address substance use and mental health disorders, including those related to Wellbutrin use.
This treatment combines medications and medical procedures with therapy to identify the root causes of addiction and develop strategies for behavior change. Substance use disorders often arise due to underlying emotional or psychological issues, and addressing these issues is key to achieving long-term recovery.
At We Level Up NJ treatment center, our specialists can provide information about dual diagnosis and detox programs designed to treat Wellbutrin withdrawal and other co-occurring mental health conditions like anxiety and depression. The goal is to provide a comprehensive approach that addresses the addiction and underlying issues, leading to long-term recovery and a better quality of life.
How Long Does Wellbutrin Stay in Your System? Testimonial Video
Jen’s Addiction Recovery Testimonial
“I wanted my life back. I was a shell of a person. I wanted to be trusted, I wanted relationships back that I lost, mainly my children and family. It started innocent enough, I got into a car accident and then I got kind of sucked into the whole, you know, medication issue with the pills.
And before I knew it, I was in a cloud. I was sucked in by addiction and with my mind, I kept thinking it was OK because a doctor was prescribing this for me, a doctor was giving me this, a doctor was giving me that. So, I didn’t think I was doing anything wrong. Level Up supports my family and my relationships with my family and they’ve helped me grown as a person.
When I first started there, I was so intimidated and kind of scared, you know? But, they’ve taught me, they’ve kind of taught me how to come into my own. And then, you know, when I get the call at the middle of the day from my twenty-one-year-old daughter, just to say ‘I love you, Mom.’, that’s amazing.”Jen’s Addiction Recovery Testimonial
Search We Level Up NJ “How Long Does Wellbutrin Stay in Your System?” Topics & Resources
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