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Does Wellbutrin Help With Anxiety? What You Should Know About Wellbutrin for Anxiety. Wellbutrin Dosage for Depression and Anxiety.

Wellbutrin for anxiety. Wellbutrin has been linked to anxiety in two ways – by alleviating anxiety and by causing it. Read on to find out more.

Wellbutrin for Anxiety

Wellbutrin (bupropion) is an antidepressant medication used for Major Depressive Disorder treatment (known as clinical depression or MDD) and seasonal affective disorder. Seasonal depressive disorder is episodes of depression that occur at the same time each year, usually in the fall and winter, but rarely may occur in the spring or summer months. Understanding the Wellbutrin side effects can help a patient better understand what to expect and ensure the person knows when they should contact their doctor or seek medical assistance.

Wellbutrin Guide


Wellbutrin Uses

Bupropion treats depression, aiming to enhance your mood and overall well-being. Its potential mechanism of action involves restoring a balanced state of specific natural chemicals (neurotransmitters) within your brain.

How To Use Wellbutrin 75 Mg Tablet

Administer this medication orally, with or without food, following your doctor’s guidance, typically three times daily. If you experience stomach discomfort, taking the drug with food is permissible. To reduce the likelihood of experiencing a seizure, it’s crucial to space your doses at least 6 hours apart, as instructed by your doctor.

The manufacturer advises against crushing, cutting, or chewing the tablet before consumption. Many similar immediate-release tablets can be crushed, cut, or chewed. Abide by your doctor’s instructions on how to take this medication.

Adhere strictly to the prescribed dosage, neither increasing nor decreasing it, and avoid taking it more frequently than recommended. Overconsumption of bupropion beyond the prescribed dose may heighten the risk of seizure occurrence.

The prescribed dosage of this medication is contingent upon your medical condition and how you respond to the treatment. Your doctor may gradually increase your dose to minimize potential side effects, such as insomnia, and reduce the risk of seizures. To avoid sleep disturbances, refrain from taking this medication too late. If sleeplessness becomes problematic, communicate this with your doctor.

To maximize the benefits of this medication, use it consistently at the exact times each day. It is imperative not to discontinue the medication without consulting your doctor, as some conditions may deteriorate when the drug is abruptly ceased. Your doctor may recommend a gradual reduction in dosage.

The complete therapeutic effects of this drug may take up to 4 or more weeks to become apparent. Continue adhering to your doctor’s instructions even after you start feeling better. If your condition fails to improve or worsens, discuss your concerns with your doctor.

Side Effects

Wellbutrin Side Effects

You might experience symptoms like nausea, vomiting, dry mouth, headaches, constipation, increased sweating, joint discomfort, a sore throat, blurred vision, an unusual taste in your mouth, diarrhea, or dizziness while taking this medication. If these effects persist or worsen, promptly inform your doctor or pharmacist.

It’s essential to remember that your doctor has prescribed this medication because they have determined that the benefits outweigh the potential side effects. Many individuals who use this medication do not encounter severe side effects.

This medication can potentially elevate your blood pressure. It is advisable to regularly monitor your blood pressure and inform your doctor if you observe high readings.

Contact your doctor without delay if you experience any severe side effects, including chest pain, fainting, a rapid or irregular heartbeat, hearing difficulties, ringing in the ears, intense headaches, changes in mental state (such as agitation, anxiety, confusion, hallucinations, or memory loss), involuntary movements (tremors), unusual weight changes, or muscle pain, tenderness, or weakness.

Seek immediate medical assistance if you encounter highly severe side effects, including eye pain, swelling, redness, dilated pupils, or alterations in vision like perceiving halos around lights during nighttime or if you experience a seizure.

Although exceedingly rare, a severe allergic reaction to this medication is possible. If you notice any signs of a severe allergic reaction, including a rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing, promptly seek medical attention.


Wellbutrin Risks

Bupropion is an antidepressant for various conditions, including depression and various mental and mood disorders, aiding in smoking cessation. Antidepressants play a crucial role in averting suicidal thoughts or attempts and providing other substantial benefits. Nonetheless, research indicates that a small percentage of individuals, particularly those under 25, who use antidepressants for any purpose may encounter new or exacerbated depression, changes in mental and mood states, or even thoughts of suicide or suicide attempts. Therefore, it is imperative to discuss with your doctor the potential risks and advantages of antidepressant therapy, even when it’s not aimed at treating a mental or mood-related condition.

Notify your doctor promptly if you observe fresh instances of depression, new or worsening psychiatric conditions, unusual shifts in behavior (including potential suicidal thoughts or attempts), or other changes in mental and mood states (such as heightened anxiety, panic episodes, sleep disturbances, irritability, feelings of hostility or anger, impulsive actions, severe restlessness, or notably rapid speech). Pay close attention to these symptoms, particularly when initiating a new antidepressant or modifying the dosage.

For individuals using bupropion to quit smoking, discontinue the medication and contact your doctor immediately if you encounter any of the aforementioned symptoms. Additionally, inform your doctor promptly if you experience these symptoms after discontinuing the treatment.


Wellbutrin Warnings

Before initiating bupropion, inform your doctor or pharmacist about any allergies related to bupropion or other substances. This product may include inactive ingredients that could trigger allergic reactions or other complications. For additional information, consult your pharmacist.

Before using this medication, provide your medical history to your doctor or pharmacist, especially if you have a history of seizures or factors that raise your seizure risk (such as head injuries, brain tumors, arteriovenous malformations, eating disorders like bulimia or anorexia nervosa), alcohol or drug dependency (including benzodiazepines, opioid pain medications, cocaine, and stimulants), diabetes, heart conditions (such as congestive heart failure, high blood pressure, or recent heart attacks), kidney disorders, liver issues (such as cirrhosis), a personal or family history of psychiatric disorders (like bipolar or manic-depressive disorder), a personal or family history of suicidal thoughts or attempts, or a personal or family history of glaucoma (particularly angle-closure type).

This medication should not be used if you are abruptly discontinuing regular usage of sedatives (including benzodiazepines like lorazepam), seizure medications, or alcohol, as this may heighten the risk of seizures.

This drug can induce dizziness or affect your coordination. The consumption of alcohol or marijuana (cannabis) can intensify dizziness and coordination impairment. Refrain from activities requiring alertness, such as driving or operating machinery, until you can do so safely. Avoid alcoholic beverages, which can also elevate the risk of seizures. If you are using marijuana (cannabis), discuss this with your doctor.

Older adults may be more vulnerable to the side effects of this medication, particularly dizziness and memory issues. Dizziness can increase the risk of falls in this age group.

While pregnant, this medication should only be used when it is unquestionably necessary. Since untreated mental or mood disorders (such as depression, seasonal affective disorder, and bipolar disorder) can be severe, refrain from discontinuing this medication unless explicitly instructed by your doctor. If you are contemplating pregnancy, become pregnant, or suspect you might be pregnant, promptly engage in a conversation with your doctor regarding the potential advantages and drawbacks of using this medication during pregnancy.

This drug can pass into breast milk and potentially adversely affect a nursing infant. It is advisable to consult your doctor before breastfeeding while using this medication.


Wellbutrin Interactions

Interactions between drugs can alter the effectiveness of your medications or increase the risk of severe side effects. This document may not encompass all conceivable drug interactions. Therefore, it is vital to maintain a comprehensive list of all the products you are using, including prescription and non-prescription medications and herbal supplements. Share this list with your doctor and pharmacist, and avoid initiating, discontinuing, or altering the dosage of any medicines without the explicit approval of your doctor.

Certain products that may interact with this medication comprise codeine, pimozide, tamoxifen, and thioridazine.

Combining MAO inhibitors with this medication can lead to a severe, potentially fatal drug interaction. Refrain from using MAO inhibitors (including isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) while undergoing treatment with this medication. In addition, most MAO inhibitors should not be taken for two weeks before or after using this medication. Consult your doctor regarding the appropriate timing for starting or ceasing this medication about MAO inhibitors.

This medication may interfere with specific medical or laboratory tests, such as brain scans for Parkinson’s disease or urine screenings for amphetamines, potentially generating inaccurate test results. Both lab personnel and your healthcare providers must be informed of your use of this drug.


Wellbutrin Overdose

In the event of an overdose with severe symptoms such as loss of consciousness or breathing difficulties, dial 911 immediately. If the situation is not as critical, promptly contact a poison control center.

The prescription drug is available in tablet form, including a sustained-release tablet (Wellbutrin SR) and an extended-release tablet (Wellbutrin XL). Wellbutrin is distinct from other common antidepressants. Its unique mechanism of action among antidepressants is thought to be due to the reuptake of dopamine and norepinephrine. 

Bupropion may be an effective antidepressant across a broad spectrum of depressive conditions. It is a safe and effective medication for treating depression in the elderly. In addition to having a favorable side effect profile, bupropion has been shown to have positive results in treating anxiety associated with depression compared with sertraline and fluoxetine.

Does Wellbutrin Help with Anxiety?

Although Wellbutrin (bupropion) is often prescribed for treating anxiety, the drug’s efficacy varies from patient to patient. Wellbutrin may be prescribed for anxiety by some doctors even though the FDA has not formally approved it for this use. Wellbutrin’s mechanism of action involves influencing mood-related neurotransmitters like norepinephrine and dopamine. Some people may find that their anxiety symptoms lessen due to this. However, people have widely varying reactions to Wellbutrin’s anti-anxiety effects.

Can Wellbutrin Cause Anxiety?

Although Wellbutrin (bupropion) is typically prescribed for depression, it may also be used to treat anxiety in some cases. Wellbutrin’s effect on anxiety in some users may be beneficial, while in others, it may increase.

Keep in mind that everyone reacts differently to medications. Anxiety may be reduced indirectly by a general uptick in one’s disposition, which may occur in some people. But for some, this could mean increased agitation, nervousness, or anxiety.

Talk to your doctor if you’re thinking about taking Wellbutrin or already taking it and experiencing increased anxiety. They will evaluate your symptoms, make dosage adjustments as necessary, and possibly recommend other treatments. Wellbutrin’s effectiveness in treating anxiety may be enhanced when used in conjunction with other treatments. Never alter your treatment plan without first speaking with your doctor.

Wellbutrin Side Effects

Here are some examples of side effects commonly reported with Wellbutrin SR and Wellbutrin XL treatment:

  • Headache.
  • Dry mouth.
  • Nausea.
  • Constipation.
  • Insomnia (trouble falling asleep or staying asleep).

Wellbutrin for Anxiety Drug Facts


Wellbutrin, known by its generic name, bupropion, is a prescription medication primarily used to treat depression. It belongs to the class of drugs known as atypical antidepressants. While its primary indication is depression, it is sometimes prescribed off-label for other conditions, such as anxiety and smoking cessation.

Mechanism of Action:

Wellbutrin works by affecting the levels of neurotransmitters in the brain, particularly norepinephrine and dopamine. It inhibits the reuptake of these neurotransmitters, leading to increased levels in the brain and potentially improving mood and other mental health symptoms.


  • Treatment of major depressive disorder.
  • Seasonal affective disorder (SAD).
  • Smoking cessation aid.
  • Off-label use for anxiety, attention deficit hyperactivity disorder (ADHD), and other conditions.

Dosage: Dosage can vary based on the specific condition being treated, individual response, and medical history. It’s essential to follow the prescribed dosage and any recommendations from your healthcare provider.

Side Effects

Common side effects of Wellbutrin may include:

  • Nausea.
  • Headache.
  • Dry mouth.
  • Insomnia.
  • Agitation.
  • Increased heart rate.
  • Weight loss.
  • Constipation.


  • Inform your doctor of any existing medical conditions or medications you are taking.
  • Do not take Wellbutrin if you have a history of seizures, eating disorders or are undergoing abrupt alcohol or sedative withdrawal.
  • Monitor for changes in mood or behavior, especially during the initial stages of treatment.


Medications like MAOIs, SSRIs, and antipsychotics may not work as well with Wellbutrin because of the potential for interactions. Tell your healthcare provider about any supplements and medications you’re currently using.

Withdrawal: Discontinuing Wellbutrin should be done under medical supervision to minimize withdrawal symptoms, including mood swings, irritability, and flu-like symptoms.

Important Notes

  • Wellbutrin may take several weeks to start showing its full effects.
  • Avoid alcohol while taking Wellbutrin, as it can increase the risk of seizures.
  • Do not stop taking Wellbutrin abruptly without consulting your doctor.

Always consult a healthcare professional before starting or discontinuing any medication. This fact sheet provides general information and is not a substitute for medical advice.

Wellbutrin for Anxiety Statistics

45.8% of American adults used a prescription drug – legally or not – within the past 30 days. Healthcare specialists generally agree that a high use rate and availability drive reported rates of prescription drug abuse, addiction, and overdose.

16.3 million

People misuse prescriptions a year.

Source: NIDA

2.0 million

People or 11.9% of people who misuse prescriptions are definitively addicted to the prescription drugs they misuse.

Source: NIDA


 Prescription drug abusers constitute 5.76% of Americans over the age of 12.

Source: NIDA

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Why Is This Medication Prescribed? 

The U.S. Food and Drugs Administration (FDA) approved uses for Wellbutrin include major depressive disorder (MDD) and seasonal depressive disorder (SAD.) The symptoms of these disorders include the following.

Major Depressive Disorder (MDD). Individuals with major depression have several of these symptoms for at least two weeks:

  • Depressed mood – feeling sad, empty, or tearful.
  • Loss of interest or pleasure in your usual activities.
  • Feeling worthless, guilty, hopeless, and helpless.
  • Sleep and eat more or less than usual (for most people, it is less).
  • Low energy, trouble concentrating, or thoughts of death (suicidal thinking).
  • Psychomotor retardation (feeling like you are moving and thinking in slow motion).
  • Psychomotor agitation (‘nervous energy’).
  • Suicidal thoughts or behaviors.

Seasonal depressive disorder (SAD): A major depressive episode with the symptoms same as MDD that also consistently recurs at particular times during the year, usually during the dark winter months.  

Wellbutrin for ADHD and Anxiety and other Off-Label Prescriptions

Wellbutrin is sometimes used off-label (using an FDA-approved drug for unapproved use to treat a medical condition) for the following conditions:

  • Attention deficit hyperactivity disorder (ADHD).
  • Depression in bipolar disorder.
  • Obesity.
  • Sexual dysfunction due to SSRI antidepressants.

Your mental health provider should justify his or her thinking in recommending an “off-label” treatment. They should be clear about the research limits around that medication and if there are any other options.

Wellbutrin For Anxiety 

Medications can affect individuals in different and more ways than one. As such, Wellbutrin has been linked to anxiety in some cases. But while it can cause anxiety in some individuals, it is an effective treatment for anxiety disorders in others. Some test subjects developed anxiety-related side effects in clinical trials shortly after taking Wellbutrin. It was also noted that these effects are exacerbated in the period following a dosage increase. These Wellbutrin anxiety-related side effects include:

  • Anxiety.
  • Insomnia.
  • Restlessness and agitation.

According to the FDA, up to 2% of the people who experienced these side effects discontinued their medication use. For some subjects, these side effects were so severe that they required treatment with anti-anxiety medication and sedatives.

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Each formulation of Wellbutrin (bupropion) for depression and anxiety has a starting dose. Depression treatment typically begins with 150 mg daily. A doctor can increase this to 450 mg per day.
Each formulation of Wellbutrin (bupropion) for depression and anxiety has a starting dose. Depression treatment typically begins with 150 mg daily. A doctor can increase this to 450 mg per day.

Wellbutrin Dosage for Depression and Anxiety

Wellbutrin (bupropion) for depression and anxiety comes in various formulations, each with its recommended starting dose. When treating depression, a starting dose of 150 mg once daily is typically recommended. Under the supervision of a medical professional, this can be increased to a maximum daily dose of 450 milligrams (mg).

Wellbutrin is not usually the first medication prescribed for anxiety. Off-label use for anxiety may involve a dose comparable to that used for depression. It’s important to talk to your doctor about any problems or side effects and follow their instructions carefully. Medication is safer and more effective when started and adjusted under medical supervision. Anxiety sufferers considering Wellbutrin should talk to their doctor about the drug’s benefits, risks, and other treatment options.

Wellbutrin Withdrawal 

Discontinuing Wellbutrin requires the advice of a doctor and should never be stopped abruptly. A gradual decrease is necessary to avoid withdrawal symptoms. Over 50 withdrawal symptoms associated with Wellbutrin have been reported. They range in severity from mild annoyances to life-threatening conditions and generally require monitoring by a medical professional.

Physical Withdrawal Symptoms

Physical withdrawal symptoms include difficulties maintaining balance, lack of coordination, increased headaches or migraines, electric shock-like or tingling sensations, and general lethargy and fatigue. These may signal a more severe condition that needs medical intervention.

Psychological Withdrawal Symptoms

Wellbutrin withdrawal may trigger psychological symptoms that are out of character for the user. Aggressive behavior that is not characteristic of the person taking the medication, irritability, hostility, and paranoia may occur. Anxiety, troubling thoughts, and worsening depression that circumstances cannot explain should be reported to the doctor. 

Highly emotional states, overreaction to everyday situations, depersonalization, and severe internal restlessness happen for some individuals. Crying spells and nervousness may surface for no apparent reason. Notify your physician immediately if you experience psychological disturbances that are not characteristic of you or have suicidal thoughts.

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What to Pair with Wellbutrin for Anxiety

Pairing Wellbutrin with other medications for anxiety should always be done under the guidance and supervision of a healthcare professional. While Wellbutrin is not a first-line treatment for anxiety disorders, some doctors may consider combining it with other medications in certain cases. Here are a few options that may be considered:

  • Selective Serotonin Reuptake Inhibitors (SSRIs): Wellbutrin works on different neurotransmitters than SSRIs. Combining Wellbutrin with an SSRI like sertraline or escitalopram may help address both depression and anxiety symptoms.
  • Buspirone: Buspirone is an anti-anxiety medication that can be used with Wellbutrin. It has a different mechanism of action and can help manage anxiety symptoms without causing sedation or dependency.
  • Benzodiazepines (Short-Term): Benzodiazepines like lorazepam or clonazepam are potent anxiety-relief medications. They are typically used short-term and can be considered for acute anxiety episodes in combination with Wellbutrin.
  • Gabapentin or Pregabalin: These medications, originally developed to treat seizures, also manage anxiety. They can be considered combined with Wellbutrin, mainly if co-occurring anxiety and neuropathic pain symptoms exist.
  • Psychotherapy: Combining Wellbutrin with psychotherapy, such as cognitive-behavioral therapy (CBT), can effectively manage anxiety. Therapy provides coping strategies and tools to address underlying causes of anxiety.
  • Lifestyle Changes: Along with medication, lifestyle modifications such as regular exercise, proper sleep, stress management techniques, and a balanced diet can play a significant role in reducing anxiety symptoms.

It’s crucial to discuss your individual needs, medical history, and preferences with your healthcare provider to determine the best course of treatment. Medication combinations should only be prescribed and adjusted by a qualified medical professional to ensure safety and effectiveness.

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Treatment For Alcohol Misuse & Mental Health Disorder

To determine the most effective ways to treat Wellbutrin side effects, especially if it is mixed with alcohol, it’s crucial first to get an accurate assessment of all the symptoms. When a mental health professional has evaluated the symptoms, it may be determined that another form of depression is present and needs a particular type of treatment. Very often, some combination of psychotherapy, medication, and lifestyle changes are effective for coping with functional.

Medically-Assisted Detox

Detox is often considered the first stage of treatment. It will help you navigate the complicated process of alcohol withdrawal but doesn’t address patterns of thought and behavior that contribute to alcohol use. Various treatment approaches and settings can help provide the ongoing support necessary to maintain long-term sobriety after you complete detox.

Cravings are very common during detox and can be challenging to overcome. This often leads to relapse. Constant medical care provided during inpatient treatment helps prevent relapse. Clinicians can provide the necessary medication and medical expertise to lessen cravings and the effects of alcohol withdrawals.

Psychotherapy for Depression

Several different modalities of psychotherapy have been used in the treatment of depression, including:

  • Cognitive Behavioral Therapy (CBT) – is an effective treatment that involves changing both the patterns of negative thoughts and the behavioral routines which are affecting the daily life of the depressed person for various forms of depression.
  • Person-Centered Therapy – a strategy that allows and encourages clients to understand and resolve their concerns in a safe, supportive environment.
  • Solution Focused Therapy – an approach interested in solutions that can be quickly implemented with a simple first step leading to further positive consequences.

Dual Diagnosis Treatment

Alcoholism and mental health disorders often co-occur. Traumatic experiences can often result in a mental health disorder and substance abuse. Dual-diagnosis rehabilitation treats both of these issues together. The best approach for the treatment of dual diagnosis is an integrated system. This strategy treats both the substance abuse problem and the mental disorder simultaneously. Regardless of which diagnosis (mental health or substance abuse problem) came first, long-term recovery will depend mainly on the treatment for both disorders done by the same team or provider.

Therapists specializing in substance use can help clients identify the underlying causes of substance abuse. 
Therapists specializing in substance use can help clients identify the underlying causes of substance abuse. 

Medication-Assisted Treatments

Medication-Assisted Treatments (MAT) for alcohol use disorder and mental health disorder are commonly used in conjunction. This includes the use of medications and other medical procedures. During your rehab, the staff from your treatment facility will help you identify what caused your addiction and teach you skills that will help you change your behavior patterns and challenge the negative thoughts that led to your addiction. Sometimes, the pressures and problems in your life make you rely on substances to help you forget about them momentarily.

If you or a loved one are struggling with long-term substance abuse and a co-occurring mental health condition such as depression and anxiety, contact one of our helpful treatment specialists today. We Level Up NJ can provide information on dual diagnosis and detox programs that may fit your needs.

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So, I didn’t think I was doing anything wrong. Level Up supports my family and my relationships with my family and they’ve helped me grown as a person. When I first started there, I was so intimidated and kind of scared, you know? But, they’ve taught me, they’ve kind of taught me how to come into my own. And then, you know, when I get the call at the middle of the day from my twenty-one-year-old daughter, just to say ‘I love you, Mom.’, that’s amazing.”

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